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Trequinsin hydrochloride

SIGMA/T2057 - ≥98%

Synonym: HL 725

CAS Number: 78416-81-6
Empirical Formula (Hill Notation): C24H27N3O3 · HCl
Molecular Weight: 441.95
MDL Number: MFCD01076563
Linear Formula: C24H27N3O3 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T2057-10MG 10 mg
 $357.00
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assay ≥98%
form powder
InChI 1S/C24H27N3O3.ClH/c1-14-9-15(2)23(16(3)10-14)25-22-13-19-18-12-21(30-6)20(29-5)11-17(18)7-8-27(19)24(28)26(22)4;/h9-13H,7-8H2,1-6H3;1H/b25-22+;
InChI key DTCZZBVPTHVXFA-OSMRDGEFSA-N
Quality Level 100 
SMILES string Cl[H].COc1cc2CCN3C(=O)N(C)C(C=C3c2cc1OC)=Nc4c(C)cc(C)cc4C
Application: Trequinsin has been used as a PDE3 inhibitor in rat juxtaglomerular cells. This study reported that trequinsin can enhance cellular cAMP content, forskolin-induced cAMP synthesis, and renin release in cells.
Biochem/physiol Actions: Phosphodiesterase III inhibitor.
Biochem/physiol Actions: Trequinsin is a strong antihypertensive agent that has a hemodynamic profile similar to that of arteriolar dilators. Trequinsin can block platelet aggregation and also inhibit tissue factor expression in human endothelial cells,.
Features and Benefits: This compound is a featured product for Cyclic Nucleotide research. Click here  to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the Phosphodiesterases  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98%
UNSPSC 41106305

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