Tyrphostin AG 879
SIGMA/T2067 - 99% (HPLC)
Synonym: α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide
CAS Number: 148741-30-4
Empirical Formula (Hill Notation): C18H24N2OS
Molecular Weight: 316.46
MDL Number: MFCD00236450
Linear Formula: C18H24N2OS
Product Type: Chemical
| assay | 99% (HPLC) |
| InChI | 1S/C18H24N2OS/c1-17(2,3)1 |
| InChI key | XRZYELWZLNAXGE-KPKJPENVSA |
| Quality Level | 100  |
| SMILES string | CC(C)(C)c1cc(C=C(/C#N)C( |
| solubility | DMSO: soluble (at 26 mg/ml) |
| H2O: insoluble |
| Application: | Tyrphostin AG 879 (AG879) has been used for studying its effect on ErbB2 receptor phosphorylation in A431 cells. This study reported that AG879 at 10 muM can cause 15% inhibition of receptor phosphorylation1. AG879 has also been used as a neurotrophic tyrosine kinase receptor inhibitor to study the disruption of Sertoli cell aggregation2. |
| Biochem/physiol Actions: | Inhibits the tyrosine kinase activity of the nerve growth factor receptor (TrkA; pp140trk) and heregulin receptor erbB-2 (HER-2). |
| Biochem/physiol Actions: | Tyrphostin AG 879 is known to block RAF-1 and Her-2 expression and exhibit anticancer functions in breast cancer cells3. Furthermore, AG879 is known to block ETK1-PAK1 interactions and the growth of RAS-induced sarcomas in nude mice4. |
| Features and Benefits: | This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Packaging: | 5 mg in glass bottle |
| Preparation Note: | Tyrphostin AG 879 is soluble in DMSO at 26/ml and is insoluble in water. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | 99% (HPLC) |
| UNSPSC | 12352200 |