Anti-Tumor Necrosis Factor Soluble Receptor I antibody produced in goat
SIGMA/T2190 - affinity isolated antibody, lyophilized powder
Synonym: Anti-TNFsRI
MDL Number: MFCD00162117
Product Type: Chemical
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | goat |
| clone | polyclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| Quality Level | 100  |
| species reactivity | mouse |
| storage temp. | −20°C |
| technique(s) | flow cytometry: suitable |
| immunohistochemistry (frozen sections): suitable | |
| western blot: suitable | |
| UniProt accession no. | P25118  |
| Biochem/physiol Actions: | The biological effects of tumor necrosis factor soluble factor (TNSF) are mediated by either type I or type II receptors. Type I receptors that are ubiquitously present on all cells whereas type II receptors are expressed only on cells of immune system and endothelial cells. Receptors of TNFSF such as TNFR1 and Fas have their own death domains that activate the apoptosis. Other receptors such as TNFR2 do not have death domains and utilize TNF associated factors (TRAFs) to activate intracellular signaling. The pathways activated via TNFsRI include NF-κB, JNK and MAPK. |
| General description: | The antibody recognizes cell surface mouse TNF RI (55 kDa) and exhibits TNF agonist activities. The antibody shows < 5% cross-reactivity with recombinant human TNF sRI and no cross-reactivity with recombinant human TNFsRII. |
| Immunogen: | recombinant mouse TNF soluble receptor I, expressed in Escherichia coli. |
| Physical form: | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5% trehalose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |