Trifluorothymidine
SIGMA/T2255 - ≥99% (HPLC)
Synonym: α,α,α-Trifluorothymidine; 2′-Deoxy-5-trifluoromethyluridine; Trifluorothymine deoxyriboside; Trifluridine
CAS Number: 70-00-8
Empirical Formula (Hill Notation): C10H11F3N2O5
Molecular Weight: 296.20
EC Number: 200-722-8
MDL Number: MFCD00006534
Linear Formula: C10H11F3N2O5
Product Type: Chemical
| assay | ≥99% (HPLC) |
| biological source | synthetic |
| form | powder |
| InChI | 1S/C10H11F3N2O5/c11-10(12 |
| InChI key | VSQQQLOSPVPRAZ-RRKCRQDMSA |
| mp | 190-193 °C (lit.) |
| Quality Level | 100  |
| SMILES string | OC[C@H]1O[C@H](C[C@@H]1O) |
| solubility | water: 50 mg/mL, clear, colorless |
| storage temp. | −20°C |
| Application: | Trifluorothymidine has been used as a component of selection medium to screen thymidine kinase (TK) mutants in lymphoma cells, human lymphoblastoid TK6 cells, and L5178Y mouse lymphoma cells. |
| Biochem/physiol Actions: | Trifluorothymidine is a thymidine analog and is light sensitive. TFT serves as a thymidine kinase substrate to study enzyme specificity and kinetics. Incorporation of phosphorylated TFT into DNA induces damage, making it useful for DNA repair studies. TFT may also be used in the inhibition of thymidylate synthase and in screening mutant thymidine kinase gene.. It elicits antitumor activity in gastrointestinal (GI) cancers and has therapeutic potential to treat herpetic keratitis. |
| Packaging: | Bottomless glass bottle. Contents are inside inserted fused cone. |
| Symbol |  GHS08 |
| Signal word | Warning |
| Hazard statements | H341 - H351 - H361d |
| Precautionary statements | P201 - P202 - P280 - P308 + P313 - P405 - P501 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-40 |
| Safety Statements | 22-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99% (HPLC) |
| mp | 190-193 °C (lit.) |
| Storage Temp. | −20°C |
| UNSPSC | 41106305 |