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Trifluorothymidine

SIGMA/T2255 - ≥99% (HPLC)

Synonym: α,α,α-Trifluorothymidine; 2′-Deoxy-5-trifluoromethyluridine; Trifluorothymine deoxyriboside; Trifluridine

CAS Number: 70-00-8
Empirical Formula (Hill Notation): C10H11F3N2O5
Molecular Weight: 296.20
EC Number: 200-722-8
MDL Number: MFCD00006534
Linear Formula: C10H11F3N2O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T2255-100MG 100 mg
 $288.00
1/EA		 Add To Favorites
45-T2255-1G 1 g
 $1880.00
1/EA		 Add To Favorites

 

assay ≥99% (HPLC)
biological source synthetic
form powder
InChI 1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1
InChI key VSQQQLOSPVPRAZ-RRKCRQDMSA-N
mp 190-193 °C (lit.)
Quality Level 100 
SMILES string OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(C(=O)NC2=O)C(F)(F)F
solubility water: 50 mg/mL, clear, colorless
storage temp. −20°C
Application: Trifluorothymidine has been used as a component of selection medium to screen thymidine kinase (TK) mutants in lymphoma cells, human lymphoblastoid TK6 cells, and L5178Y mouse lymphoma cells.
Biochem/physiol Actions: Trifluorothymidine is a thymidine analog and is light sensitive. TFT serves as a thymidine kinase substrate to study enzyme specificity and kinetics. Incorporation of phosphorylated TFT into DNA induces damage, making it useful for DNA repair studies. TFT may also be used in the inhibition of thymidylate synthase and in screening mutant thymidine kinase gene.. It elicits antitumor activity in gastrointestinal (GI) cancers and has therapeutic potential to treat herpetic keratitis.
Other Notes: Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. T2255.pdf  Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin. 
Packaging: Bottomless glass bottle. Contents are inside inserted fused cone.
Purity ≥99% (HPLC)
mp 190-193 °C (lit.)
Storage Temp. −20°C
UNSPSC 41106305

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