Tetraethylammonium chloride
SIGMA/T2265 - ≥98% (titration)
Synonym: TEA chloride
CAS Number: 56-34-8
Empirical Formula (Hill Notation): C8H20ClN
Molecular Weight: 165.70
EC Number: 200-267-5
MDL Number: MFCD00011828
Linear Formula: (C2H5)4N(Cl)
Product Type: Chemical
assay | ≥98% (titration) |
biological source | synthetic (organic) |
color | white to light yellow |
form | powder |
InChI | 1S/C8H20N.ClH/c1-5-9(6-2, |
InChI key | YMBCJWGVCUEGHA-UHFFFAOYSA |
Quality Level | 200 ![]() |
SMILES string | [Cl-].CC[N+](CC)(CC)CC |
technique(s) | blocking: suitable |
Application: | Tetraethylammonium chloride (TEAC) has been used: • used for inhibition of peroxynitrite induced relaxation in rat aorta rings • as a pharmacological blocker of K+ current and Ca2+ induced K+ current in antennal lobe neurons • for the induction of TEAC sensitive currents in cochlear inner hair cells digested with proteolytic enzymes and analyze its properties |
Biochem/physiol Actions: | Blocks K+ channels; blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K+ currents. |
Biochem/physiol Actions: | Tetraethylammonium chloride (TEAC) blocks K+ channels non-specifically. In rat aorta rings, tetraethylammonium inhibits relaxation induced by peroxynitrite. It blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K+ currents. TEAC can increase the contractility and mobility of colon and rectum and is a therapeutic option for Hirschsprung′s disease patients. TEAC reduces the inflammatory responses, improves cardiac, vascular and hemodynamic properties during early sepsis in animals. TEAC has cytotoxic and anti-proliferative potential and induces apoptosis in glioma cells by downregulating B-cell lymphoma-2 (Bcl-2) and upregulating Bcl-2 associated X (Bax). |
Caution: | moisture sensitive, handle under argon |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H315 - H319 |
Precautionary statements | P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313 |
Hazard Codes | Xn |
Risk Statements | 22-36/37/38 |
Safety Statements | 26-36 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | 201.2 °F - closed cup |
Flash Point(C) | 94 °C - closed cup |
Purity | ≥98% (titration) |
UNSPSC | 12352107 |