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Tetraethylammonium chloride

SIGMA/T2265 - ≥98% (titration)

Synonym: TEA chloride

CAS Number: 56-34-8
Empirical Formula (Hill Notation): C8H20ClN
Molecular Weight: 165.70
EC Number: 200-267-5
MDL Number: MFCD00011828
Linear Formula: (C2H5)4N(Cl)
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T2265-25G 25 g
 $68.30
1/EA		 Add To Favorites
45-T2265-100G 100 g
 $184.00
1/EA		 Add To Favorites

 

assay ≥98% (titration)
biological source synthetic (organic)
color white to light yellow
form powder
InChI 1S/C8H20N.ClH/c1-5-9(6-2,7-3)8-4;/h5-8H2,1-4H3;1H/q+1;/p-1
InChI key YMBCJWGVCUEGHA-UHFFFAOYSA-M
Quality Level 200 
SMILES string [Cl-].CC[N+](CC)(CC)CC
technique(s) blocking: suitable
Application: Tetraethylammonium chloride (TEAC) has been used:
• used for inhibition of peroxynitrite induced relaxation in rat aorta rings
• as a pharmacological blocker of K+ current and Ca2+ induced K+ current in antennal lobe neurons
• for the induction of TEAC sensitive currents in cochlear inner hair cells digested with proteolytic enzymes and analyze its properties
Biochem/physiol Actions: Blocks K+ channels; blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K+ currents.
Biochem/physiol Actions: Tetraethylammonium chloride (TEAC) blocks K+ channels non-specifically. In rat aorta rings, tetraethylammonium inhibits relaxation induced by peroxynitrite. It blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K+ currents. TEAC can increase the contractility and mobility of colon and rectum and is a therapeutic option for Hirschsprung′s disease patients. TEAC reduces the inflammatory responses, improves cardiac, vascular and hemodynamic properties during early sepsis in animals. TEAC has cytotoxic and anti-proliferative potential and induces apoptosis in glioma cells by downregulating B-cell lymphoma-2 (Bcl-2) and upregulating Bcl-2 associated X (Bax).
Disclaimer: moisture sensitive, handle under argon
Other Notes: 2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research 
Purity ≥98% (titration)
UNSPSC 12352107

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