Synonym: 3,3′,5,5″-Tetraiodo-L-thyronine; 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine; T4
CAS Number: 51-48-9
Empirical Formula (Hill Notation): C15H11I4NO4
Molecular Weight: 776.87
EC Number: 200-101-1
MDL Number: MFCD00002595
Linear Formula: HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H
Product Type: Chemical
| assay |
≥98% (HPLC) |
| biological source |
synthetic |
| form |
powder |
| InChI |
1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 |
| InChI key |
XUIIKFGFIJCVMT-LBPRGKRZSA-N |
| mp |
223 °C (dec.) (lit.) |
| Quality Level |
200  |
| shipped in |
ambient |
| SMILES string |
N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O |
| solubility |
4 M NH4OH in methanol: 50 mg/mL, clear to hazy, yellow |
| sterility |
non-sterile |
| storage temp. |
room temp |
| technique(s) |
cell culture | mammalian: suitable |
| Application: |
L-Thyroxine was used to study the light-induced hormone conversion of T4 to T3 in regulation of photoperiodic response of gonads in Japanese quail. The product was used as a test compound for studying the impact of numerous hormones on the surface morphology of rat testicular cells in culture. |
| Biochem/physiol Actions: |
L-Thyroxine (T4) and triiodo-L-thyronine (T3) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis. |
| Biochem/physiol Actions: |
L-Thyroxine is an iodine containing hormone produced from thyroglobulin in the thyroid follicular cells. L-Thyroxine reduces total cholesterol level, low-density lipoprotein cholesterol as well as waist to hip ratio in subclinical hypothyroidism pateints. Hence, facilitates in improving cardiovascular risk factor as well as can enhance symptoms of tiredness. |
| Other Notes: |
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. T2376.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin. |
| Packaging: |
1, 5 g in glass bottle |
| Packaging: |
100, 500 mg in glass bottle |
| Packaging: |
Bottomless glass bottle. Contents are inside inserted fused cone. |
| Preparation Note: |
L-Thyroxine dissolves in 4M ammonium hydroxide in Methanol at 50 mg/ml to yield a clear to hazy yellow to dark yellow solution. |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| mp |
223 °C (dec.) (lit.) |
| Storage Temp. |
room temp |
| UNSPSC |
51111800 |
