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Talsaclidine

SIGMA/T2452 - ≥98% (HPLC), oil

Synonym: (R)-3-(2-Propynyloxy)-1-Azabicyclo[2.2.2]octane; WAL 2014

CAS Number: 147025-53-4
Empirical Formula (Hill Notation): C10H15NO
Molecular Weight: 165.23
Linear Formula: C10H15NO
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-T2452-10MG 10 mg
$0.00
1/EA
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45-T2452-25MG 25 mg
$0.00
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assay ≥98% (HPLC)
form oil
InChI 1S/C10H15NO/c1-2-7-12-10-8-11-5-3-9(10)4-6-11/h1,9-10H,3-8H2/t10-/m0/s1
InChI key XVFJONKUSLSKSW-JTQLQIEISA-N
Quality Level 100 
SMILES string C#CCO[C@H]1CN2CC[C@H]1CC2
solubility DMSO: >5 mg/mL
storage temp. −20°C
Biochem/physiol Actions: Talsaclidine aids in promoting the nonamyloidogenic α-secretase pathway in model systems. It is more effective in stimulating muscarinic M 1 receptors than M 2 and M 3 receptors. In anesthetized guinea pigs, talsaclidine has no bronchospastic effects, but it produces contracture in isolated tracheal muscle. Talsaclidine is considered a potential candidate for cholinergic replacement therapy.
Biochem/physiol Actions: Talsaclidine is a M1 selective muscarinic receptor agonist. Concentration-dependently, talsaclidine increases the release of APPs and dose-dependently. Talsaclidine decreases Aβ formation and decreases cerebrospinal fluid Aβ in AD patients.
Features and Benefits: This compound is featured on the Acetylcholine Receptors (Muscarinic)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 10, 25 mg in glass bottle
Packaging: Packaged under argon
Preparation Note: Talsaclidine is soluble in DMSO at a concentration that is greater than 5 mg/ml.
Symbol GHS05  GHS05
Signal word Danger
Hazard statements H318
Precautionary statements P280 - P305 + P351 + P338
Hazard Codes Xi
Risk Statements 41
Safety Statements 26-39
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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