T3MG
SIGMA/T2455
Synonym: (±)
CAS Number: 63088-04-0
Empirical Formula (Hill Notation): C6H11NO4
Molecular Weight: 161.16
MDL Number: MFCD09836097
Linear Formula: C6H11NO4
Product Type: Chemical
| color | white to off-white |
| form | powder |
| InChI | 1S/C6H11NO4/c1-3(2-4(8)9) |
| InChI key | FHJNAFIJPFGZRI-WVZVXSGGSA |
| Quality Level | 100  |
| SMILES string | C[C@@H](CC(O)=O)[C@@H](N) |
| solubility | H2O: >1.5 mg/dL |
| storage temp. | room temp |
| suitability | suitable for TLC (single spot) |
| Biochem/physiol Actions: | T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1, EAAT2, and EAAT4. T3MG has long been utilized as a gold standard in the study of general EAAT function. It has more recently been shown to be selective for EAAT2 and EAAT4 as compared to EAAT1 and EAAT3 in electrophysiology and glutamate/aspartate uptake assays. Although there are other EAAT2-selective compounds, this is the first tool with selectivity for EAAT4. T3MG is not a substrate for the transporters themselves, nor does it have activity at glutamate ion channels. |
| Features and Benefits: | This compound is featured on the Excitatory Amino Acid Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 5, 25 mg in glass bottle |
| Preparation Note: | T3MG dissolves in water at a concentration that is greater than 1.5 mg/ml. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 - H335 |
| Precautionary statements | P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |