Synonym: (±)-5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione; CS-045
CAS Number: 97322-87-7
Empirical Formula (Hill Notation): C24H27NO5S
Molecular Weight: 441.54
MDL Number: MFCD00878416
Linear Formula: C24H27NO5S
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T2573-5MG
assay |
≥98% (HPLC) |
color |
white to off-white |
form |
powder |
InChI |
1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28) |
InChI key |
GXPHKUHSUJUWKP-UHFFFAOYSA-N |
originator |
Pfizer |
Quality Level |
200 |
SMILES string |
Cc1c(C)c2OC(C)(CCc2c(C)c1O)COc3ccc(CC4SC(=O)NC4=O)cc3 |
solubility |
DMSO: 20 mg/mL |
Application: |
Troglitazone has been used as a reagent in adipocyte differentiation medium. |
Biochem/physiol Actions: |
PPARγ agonist; anti-diabetic thiazolidinedione (TZD) with anti-inflammatory and anti-tumor activity; induces apoptosis via a p53 pathway. |
Features and Benefits: |
This compound is featured on the Nuclear Receptors (PPARs) and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
Features and Benefits: |
This compound was developed by Pfizer . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
General description: |
Troglitazone is used to treat type 2 diabetes. It is associated with liver injury. Troglitazone functions as an inducer of cytochrome3A. |
Packaging: |
5 mg in glass bottle |
Preparation Note: |
Studies using troglitazone have reported that it can increase AMP-activated protein kinase (pAMPK) and phosphorylated acetyl-CoA carboxylase in isolated rat extensor digitorum longus muscles1. Furthermore, analysis of troglitazone-mediated autophagy is reported to correlate with the stimulation of AMPK α2. |
RIDADR |
NONH for all modes of transport |
WGK Germany |
WGK 2 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |
Purity |
≥98% (HPLC) |
UNSPSC |
12352200 |