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Temozolomide

SIGMA/T2577 - ≥98% (HPLC)

Synonym: 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide; 3-Methyl-4-oxo-8-imidazolo[5,1-d][1,2,3,5]tetrazinecarboxamide; 4-Methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide; 8-Carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one; NSC 362856

CAS Number: 85622-93-1
Empirical Formula (Hill Notation): C6H6N6O2
Molecular Weight: 194.15
MDL Number: MFCD00866492
Linear Formula: C6H6N6O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T2577-25MG 25 mg
 $131.00
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45-T2577-100MG 100 mg
 $363.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T2577-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T2577-25MG

 

assay ≥98% (HPLC)
color white to light brown
form powder
InChI 1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
InChI key BPEGJWRSRHCHSN-UHFFFAOYSA-N
originator Schering Plough
Quality Level 100 
SMILES string CN1N=Nc2c(ncn2C1=O)C(N)=O
solubility DMSO: 10 mg/mL, clear
  H2O: insoluble
storage temp. 2-8°C
Application: Temozolomide has been used for analyzing drug resistance mechanisms in glioblastoma cell lines15,16.
Biochem/physiol Actions: Temozolomide is a DNA methylating agent and drug resistance-modifying agent; anti-tumor and anti-angiogenic. Temozolomide induces G2/M arrest and apoptosis through adduction of a methyl group to O6 position of guanine in genomic DNA and functional inactivation of DNA repair protein O(6)-alkylguanine DNA alkyltransferase (AGT) in base excision repair (BER) pathway.
Features and Benefits: This compound is a featured product for Apoptosis research. Click here  to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound was developed by Schering Plough . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 25, 100 mg in glass bottle
Preparation Note: Temozolomide is soluble in DMSO at a concentration that is greater than 20 mg/ml. It is insoluble in water.
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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