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Topotecan hydrochloride hydrate

SIGMA/T2705 - ≥98% (HPLC and enzymatic)

Synonym: 9-[(dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin hydrochloride hydrate; NSC-609669 hydrochloride hydrate; SKF-104864A hydrochloride hydrate; hycamptamine hydrochloride hydrate

CAS Number: 123948-87-8 (free base)
Empirical Formula (Hill Notation): C23H23N3O5 · xHCl · yH2O
Molecular Weight: 421.45 (anhydrous free base basis)
MDL Number: MFCD00870670
Linear Formula: C23H23N3O5 · xHCl · yH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T2705-10MG 10 mg
 $84.10
1/EA		 Add To Favorites
45-T2705-50MG 50 mg
 $335.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC and enzymatic)
color yellow
form powder
InChI 1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1
InChI key UCFGDBYHRUNTLO-QHCPKHFHSA-N
originator GlaxoSmithKline
Quality Level 100 
solubility DMSO: ≥20 mg/mL
storage condition desiccated
  protect from light
storage temp. −20°C
Application: Topotecan has been used as a positive control for the identification and analysis of HIF-1α and VEGF inhibitors in human glioma cells under hypoxic conditions1. It has also been used for in vitro apoptosis assays in PA317 cells2.
Biochem/physiol Actions: Topotecan is a topoisomerase I inhibitor and an apoptosis inducer. It is a potent antineoplastic agent.
Features and Benefits: This compound is a featured product for ADME Tox and Apoptosis research. Discover more featured ADME Tox  and Apoptosis  products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 10, 50 mg in glass bottle
Preparation Note: Topotecan hydrochloride hydrate is soluble in DMSO at a concentration that is greater than or equal to 20 mg/ml.
Symbol GHS08  GHS08
Signal word Warning
Hazard statements H341
Precautionary statements P201 - P308 + P313
Risk Statements 46-48
Safety Statements 22-36
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC and enzymatic)
Storage Temp. −20°C
UNSPSC 12352200

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