Tomatidine hydrochloride

SIGMA/T2909 - ≥85%

Synonym: 3β-Hydroxy-5α-tomatidane hydrochloride; 5α-Tomatidan-3β-ol hydrochloride

CAS Number: 6192-62-7
Empirical Formula (Hill Notation): C₂₇H₄₅NO₂ · HCl
Molecular Weight: 452.11
MDL Number: MFCD00133866
Linear Formula: C₂₇H₄₅NO₂ · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-T2909-25MG	25 mg	$75.20 1/EA	Add To Favorites
45-T2909-100MG	100 mg	$259.00 1/EA	Add To Favorites

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This image depicts SKU: T2909-100MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥85%
InChI	1S/C27H45NO2.ClH/c1-16-7-12-27(28-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(29)8-10-25(18,3)21(20)9-11-26(22,24)4;/h16-24,28-29H,5-15H2,1-4H3;1H/t16-,17-,18-,19-,20+,21-,22-,23-,24-,25-,26-,27+;/m0./s1
InChI key	SXXHVPYRDFJKPG-XRWUXUKGSA-N
Quality Level	100
SMILES string	Cl[H].[H][C@@]12CC[C@]3([H])[C@]([H])(CC[C@@]4(C)[C@@]3([H])C[C@]5([H])O[C@]6(CC[C@H](C)CN6)[C@@H](C)[C@]45[H])[C@@]1(C)CC[C@H](O)C2
storage temp.	2-8°C

Application:	Tomatidine hydrochloride has been used: • to evaluate its effect on nasopharyngeal carcinoma using cell proliferation and flow cytometry assay • as a negative control in the non-specific inhibition on hedgehog signaling in hepatocellular carcinoma cell lines • as a control for cell growth assay and expression studies in pancreatic cancer cells
Biochem/physiol Actions:	Potent inhibitor of Staphylococcus aureus small-colony variants typically seen as complications of cystic fibrosis, with little or no effect on normal S. aureus strains. Also shows antiinflammatory activity by indirectly inhibiting iNOS and COX-2 pathways.
Biochem/physiol Actions:	Tomatidine induces the anti-oxidant nuclear factor E2-related factor 2 (Nrf2) and mitophagy, favoring the delay in aging process in C.elegans. It is an inhibitor of muscle atrophy and promotes anabolism in muscle by activating mammalian target of rapamycin complex 1 (mTORC1). It may be useful for treating skeletal muscle atrophy.
General description:	Tomatidine is a glycoalkaloid and an aglycone metabolite of tomatine present in high levels in unripe tomato.
Packaging:	25, 100 mg in poly bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264 - P270 - P301 + P312 - P501
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥85%
Storage Temp.	2-8°C
UNSPSC	12352200

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