Synonym: 9,10-Dimethoxy-1,3,4,6,7,11b-hexahydro-3-isobutyl-(rel 3R,11bR)-2H-benzo[a]quinolizin-2-one
CAS Number: 58-46-8
Empirical Formula (Hill Notation): C19H27NO3
Molecular Weight: 317.42
EC Number: 200-383-6
MDL Number: MFCD08461052
Linear Formula: C19H27NO3
Product Type: Chemical
| assay |
≥98% (HPLC) |
| form |
solid |
| InChI |
1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3/t14-,16-/m1/s1 |
| InChI key |
MKJIEFSOBYUXJB-GDBMZVCRSA-N |
| originator |
Roche |
| Quality Level |
100  |
| SMILES string |
COc1cc2CCN3C[C@@H](CC(C)C)C(=O)CC3c2cc1OC |
| solubility |
DMSO: >10 mg/mL |
| |
H2O: insoluble |
| storage temp. |
2-8°C |
| Application: |
Tetrabenazine has been used for dopamine uptake assays in mouse brain cells1. Tetrabenazine has also been used for non-specific binding assays in postnuclear supernatants derived from PC-12 and CV-1 cells2. |
| Biochem/physiol Actions: |
Tetrabenazine is a reversible type 2 vesicular monoamine transporter (VMAT) inhibitor. |
| Biochem/physiol Actions: |
Tetrabenazine is a reversible type 2 vesicular monoamine transporter (VMAT) inhibitor. It depletes dopamine stores. |
| Features and Benefits: |
This compound was developed by Roche . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| Packaging: |
10, 50 mg in glass bottle |
| Preparation Note: |
Tetrabenazine is soluble in DMSO at a concentration that is greater than 10 mg/ml and is insoluble in water. |
| Symbol |
 GHS07 |
| Signal word |
Warning |
| Hazard statements |
H302 |
| Precautionary statements |
P264 - P270 - P301 + P312 - P501 |
| Hazard Codes |
Xn |
| Risk Statements |
22 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
