TRO 19622
SIGMA/T3077 - ≥98% (HPLC), solid
Synonym: Cholest-4-en-3-one, oxime; NSC 21311; Olesoxime
CAS Number: 22033-87-0
Empirical Formula (Hill Notation): C27H45NO
Molecular Weight: 399.65
Linear Formula: C27H45NO
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | white |
| form | solid |
| InChI | 1S/C27H45NO/c1-18(2)7-6-8 |
| InChI key | QNTASHOAVRSLMD-SGWCAAJKSA |
| Quality Level | 100  |
| solubility | DMSO: >10 mg/mL |
| storage temp. | −20°C |
| Application: | TRO 19622 has been used as a mitochondrial permeability transition pore inhibitor in mouse neurons2. TRO 19622 is also known to stimulate myelin repair in rat models of demyelination3. |
| Biochem/physiol Actions: | TRO 19622 can decrease axonal degradation and enhance the rescue of motor nerve conduction in peripheral neuropathy. Furthermore, TRO 19622 can reverse neuropathic pain and tactile allodynia in rat models of diabetes and chemotherapy-induced neuropathic pain4. |
| Biochem/physiol Actions: | TRO19622 ia a neuroprotective agent for motor neurons; candidate therapeutic for amyotrophic lateral sclerosis (ALS). |
| Packaging: | 5, 25 mg in glass bottle |
| Preparation Note: | TRO 19622 is soluble in DMSO at a concentration that is greater than 10 mg/ml. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |