Tetrahydrofolic acid
SIGMA/T3125 - ≥65% (when packaged), powder
Synonym: 5,6,7,8-
CAS Number: 135-16-0
Empirical Formula (Hill Notation): C19H23N7O6
Molecular Weight: 445.43
EC Number: 205-181-1
MDL Number: MFCD00135583
Linear Formula: C19H23N7O6
Product Type: Chemical
Representative of vacuum-sealed amber ampule packaging. Non-uniform tips are an inherent feature in this sealing process.
| biological source | synthetic |
| color | faintly yellow to light brown |
| concentration | ≥65% (when packaged) |
| form | powder |
| InChI | 1S/C19H23N7O6/c20-19-25-1 |
| InChI key | MSTNYGQPCMXVAQ-KIYNQFGBSA |
| Quality Level | 200  |
| SMILES string | NC1=NC2=C(NC(CNc3ccc(cc3) |
| solubility | 0.1 M phosphate pH 7.0: soluble-5 mg/mL, clear to slightly hazy, light yellow to brownish-yellow |
| storage temp. | −20°C |
| Application: | Tetrahydrofolic acid has been used to determine the inhibitory effect of tetrahydrofolate on polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs). A recent use of tetrahydrofolate (THF) is for studying the activation of riboswitches. |
| Application: | Tetrahydrofolic acid may also be used as a standard to generate calibration curve to quantify the folate types produced by Streptococcus thermophilus in milk cultures using high-performance liquid chromatography (HPLC). It is also suitable for use in the enzymatic assay of formate-tetrahydrofolate ligase from M. extorquens (MeFtfL). |
| Biochem/physiol Actions: | Tetrahydrofolic acid is the parent molecule of the folate derivatives that donate one-carbon units to amino acids, nucleic acids, and lipids. Tetrahydrofolate metabolites participate in the synthesis of purine and pyrimidine and in synthesis and conversion of amino acids |
| Packaging: | Sealed ampule. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352204 |