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Tetrahydrofolic acid

SIGMA/T3125 - ≥65% (when packaged), powder

Synonym: 5,6,7,8-Tetrahydropteroyl-L-glutamic acid; THF

CAS Number: 135-16-0
Empirical Formula (Hill Notation): C19H23N7O6
Molecular Weight: 445.43
EC Number: 205-181-1
MDL Number: MFCD00135583
Linear Formula: C19H23N7O6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T3125-25MG 25 mg
 $68.80
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45-T3125-100MG 100 mg
 $190.00
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45-T3125-1G 1 g
 $970.00
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Representative of vacuum-sealed amber ampule packaging. Non-uniform tips are an inherent feature in this sealing process.

 

assay ≥65% (when packaged)
color faintly yellow to light brown
form powder
InChI 1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t11?,12-/m0/s1
InChI key MSTNYGQPCMXVAQ-KIYNQFGBSA-N
Quality Level 200 
SMILES string NC1=NC2=C(NC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CN2)C(=O)N1
storage temp. −20°C
Application: Tetrahydrofolic acid has been used to determine the inhibitory effect of tetrahydrofolate on polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs). A recent use of tetrahydrofolate (THF) is for studying the activation of riboswitches.
Application: Tetrahydrofolic acid may also be used as a standard to generate calibration curve to quantify the folate types produced by Streptococcus thermophilus in milk cultures using high-performance liquid chromatography (HPLC). It is also suitable for use in the enzymatic assay of formate-tetrahydrofolate ligase from M. extorquens (MeFtfL).
Biochem/physiol Actions: Tetrahydrofolic acid is the parent molecule of the folate derivatives that donate one-carbon units to amino acids, nucleic acids, and lipids. Tetrahydrofolate metabolites participate in the synthesis of purine and pyrimidine and in synthesis and conversion of amino acids
Other Notes: Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. T3125.pdf   Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin. 
Packaging: Sealed ampule.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥65% (when packaged)
Storage Temp. −20°C
UNSPSC 12352204

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