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Torsemide

SIGMA/T3202 - ≥98% (HPLC), solid

Synonym: Demadex; N-[[(1-Methylethyl)amino]carbonyl]-4-[(3-methylphenyl)amino]-3-pyridinesulfonamide

CAS Number: 56211-40-6
Empirical Formula (Hill Notation): C16H20N4O3S
Molecular Weight: 348.42
MDL Number: MFCD00866166
Linear Formula: C16H20N4O3S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T3202-10MG 10 mg
 $156.00
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45-T3202-50MG 50 mg
 $490.00
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assay ≥98% (HPLC)
form solid
InChI 1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)
InChI key NGBFQHCMQULJNZ-UHFFFAOYSA-N
originator Roche
Quality Level 100 
SMILES string CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2
solubility DMSO: soluble 18 mg/mL
  H2O: insoluble
Application: Torsemide has been used as an inhibitor of Na+ Cl- co-transporter in transgenic Arabidopsis thaliana plants1.
Biochem/physiol Actions: Torsemide functions in the thick ascending limb of the loop of Henle and enhances the excretion of sodium, chloride and water from the luminal side of the cells. Furthermore, torsemide can treat oedematous conditions that are associated with diseases such as liver cirrhosis, kidney disorders and chronic congestive heart failure2.
Biochem/physiol Actions: Torsemide is a loop diuretic of the pyridine-sulfonylurea class with antialdosteronergic properties and inhibitor of the Na+/K+/2Cl- carrier system.
Features and Benefits: This compound was developed by Roche . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Other Notes: Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. T3202.pdf  Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin. 
Packaging: 10, 50 mg in glass bottle
Preparation Note: Torsemide is soluble in DMSO at 18 mg/ml and is insoluble in water.
Purity ≥98% (HPLC)
UNSPSC 12352200

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