Tetramethylammonium chloride solution
SIGMA/T3411 - Molecular Biology
Synonym: N,N,N-
CAS Number: 75-57-0
MDL Number: MFCD00011628
Product Type: Chemical
| concentration | 5 M |
| foreign activity | DNase, RNase, none detected |
| grade | Molecular Biology |
| InChI | 1S/C4H12N.ClH/c1-5(2,3)4; |
| InChI key | OKIZCWYLBDKLSU-UHFFFAOYSA |
| Quality Level | 200  |
| SMILES string | [Cl-].C[N+](C)(C)C |
| Application: | Tetramethylammonium chloride solution (TMAC) has been used: • in the preparation of hybridization cocktail for array hybridization and scanning • in next-generation sequencing (NGS), and genome-wide unbiased identification of double-stranded breaks enabled by sequencing (GUIDE-seq) library preparation • in the preparation of TMAC buffer and bead hybridization mixture for hybridization and detection |
| General description: | Tetramethylammonium binds AT-rich DNA polymers while concomitantly abolishing the preferential melting of AT versus GC base pairs. It is supplied as a 0.2 μm filtered solution in 18 megohm water. |
| Symbol |    GHS06,GHS08,GHS09 |
| Signal word | Danger |
| Hazard statements | H301 + H311 - H315 - H370 - H411 |
| Precautionary statements | P273 - P280 - P301 + P310 + P330 - P302 + P352 + P312 |
| Hazard Codes | T,N |
| Risk Statements | 24/25-38-39/25-51/53 |
| Safety Statements | 36/37-45-61 |
| RIDADR | UN 2810 6.1 / PGIII |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| UNSPSC | 12352107 |