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Tyrphostin AG 490

SIGMA/T3434 - solid

Synonym: 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide; 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide

CAS Number: 133550-30-8
Empirical Formula (Hill Notation): C17H14N2O3
Molecular Weight: 294.30
MDL Number: MFCD00236452
Linear Formula: C17H14N2O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T3434-5MG 5 mg
 $96.10
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45-T3434-25MG 25 mg
 $426.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
biological source synthetic (organic)
color yellow
form solid
InChI 1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+
InChI key TUCIOBMMDDOEMM-RIYZIHGNSA-N
Quality Level 200 
SMILES string Oc1ccc(cc1O)C=C(/C#N)C(=O)NCc2ccccc2
solubility DMSO: soluble 10 mg/ml, clear, yellow
  ethanol: 5 mg/mL
  H2O: insoluble
storage temp. −20°C
Application: Tyrphostin AG has been used to block IL-6 cytokine signaling to study its effects on glial cell reactivity5. AG 490 has also been used as a JAK2 inhibitor in human umbilical vein endothelial cells6.
Biochem/physiol Actions: Jak-2 protein tyrosine kinase (PTK) inhibitor. Inhibits interleukin 2 (IL-2) driven mitogenesis and triggers apoptosis of tumor cells in Sezary syndrome, a leukemic variant of cutaneous T cell lymphoma.
Caution: Photosensitive
Features and Benefits: This compound is a featured product for Kinase Phosphatase Biology research. Click here  to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the JAKs  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 25 mg in poly bottle
Packaging: 5 mg in glass bottle
Preparation Note: Tyrphostin AG 490 is soluble in ethanol at 5 mg/ml and is insoluble in water. It is also soluble in DMSO at 10 mg/ml and yields a clear, yellow solution.
Hazard Codes T,N
Risk Statements 25-50
Safety Statements 45-61
RIDADR UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s.,
WGK Germany WGK 3
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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