Thiolutin

SIGMA/T3450 - from Streptomyces luteosporeus, ≥95% (HPLC)

Synonym: Farcinicin; N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl); Propiopyvothine

CAS Number: 87-11-6
Empirical Formula (Hill Notation): C₈H₈N₂O₂S₂
Molecular Weight: 228.29
MDL Number: MFCD07370147
Linear Formula: C₈H₈N₂O₂S₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-T3450-1MG	1 mg	$394.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	fungi
assay	≥95% (HPLC)
biological source	Streptomyces luteosporeus
form	solid
InChI	1S/C9H10N2O2S2/c1-3-6(12)10-7-8-5(4-14-15-8)11(2)9(7)13/h4H,3H2,1-2H3,(H,10,12)
InChI key	UGZYFXMSMFMTSM-UHFFFAOYSA-N
mode of action	enzyme \| inhibits
Quality Level	200
shipped in	wet ice
SMILES string	CCC(=O)NC1=C2SSC=C2N(C)C1=O
solubility	DMSO: 0.90 - 1.10 mg/ml, clear, yellow
storage temp.	−20°C

Application:	Thiolutin has been used as a polymerase II inhibitor: • to study its effects on yeast cells to calculate transcript half-life • to study its effects on transcription during germination in budding yeast • to study its effects on cell adhesion in zebrafish
Biochem/physiol Actions:	Sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. It was found to inhibit in vitro RNA synthesis directed by all three yeast RNA polymerases (I, II, and III). Thiolutin is also an inhibitor of mannan and glucan formation in Saccharomyces cerevisiae and used for the analysis of mRNA stability. Studies have shown that thiolutin inhibits adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin and thus suppresses tumor cell-induced angiogenesis in vivo.
Packaging:	1 mg in glass bottle
Preparation Note:	Thiolutin dissolves in DMSO at 0.90 - 1.10 mg/ml to yield a clear, yellow solution.

Symbol	GHS06
Signal word	Danger
Hazard statements	H300
Precautionary statements	P264 - P301 + P310
Hazard Codes	T+
Risk Statements	28
Safety Statements	45
RIDADR	UN 2811 6.1 / PGII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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