Tumor Necrosis Factor Soluble Receptor I (TNF sRI) from mouse
SIGMA/T3564 - >97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
MDL Number: MFCD01324859
Product Type: Chemical
assay | >97% (SDS-PAGE) |
biological source | mouse |
form | lyophilized powder |
impurities | endotoxin, tested |
mol wt | 21 kDa |
packaging | pkg of 50 μg |
potency | 0.5-1.5 μg/mL ED50 |
Quality Level | 200 ![]() |
recombinant | expressed in E. coli |
storage condition | avoid repeated freeze/thaw cycles |
storage temp. | −20°C |
technique(s) | cell culture | mammalian: suitable |
UniProt accession no. | P06804 ![]() ![]() |
Analysis Note: | The biological activity is measured by its ability to inhibit the recombinant mouse TNF-α mediated cytotoxicity in mouse L929 cells, in the presence of the metabolic inhibitor actinomycin D. |
Application: | Tumor Necrosis Factor Soluble Receptor I (TNF sRI) from mouse plays a pivotal role in the signaling of apoptosis and NF-κB activation because of its “death domain” present at the intracellular portion. |
Biochem/physiol Actions: | Tumor Necrosis Factor Soluble Receptor I (TNF sRI) from mouse belongs to TNF family of receptors and has a pivotal role in neutralizing the biological activities of both TNF-α and TNF-β. Soluble tumor necrosis factor receptor along with intrathecal interleukin-1 receptor antagonist shows an anti-allodynic action in rat L5 spinal nerve transection model of neuropathic pain. |
Physical form: | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 2.5 mg bovine serum albumin |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | >97% (SDS-PAGE) |
Storage Temp. | −20°C |
UNSPSC | 51111800 |