Toyocamycin
SIGMA/T3580 - ≥98% (HPLC), from Streptomyces rimosus
Synonym: 4-
CAS Number: 606-58-6
Empirical Formula (Hill Notation): C12H13N5O4
Molecular Weight: 291.26
MDL Number: MFCD00866513
Linear Formula: C12H13N5O4
Product Type: Chemical
antibiotic activity spectrum | fungi |
assay | ≥98% (HPLC) |
biological source | Streptomyces rimosus |
form | solid |
InChI | 1S/C12H13N5O4/c13-1-5-2-1 |
InChI key | XOKJUSAYZUAMGJ-WOUKDFQISA |
mode of action | DNA synthesis | interferes |
Quality Level | 200 ![]() |
SMILES string | Nc1ncnc2n(cc(C#N)c12)[C@@ |
solubility | aqueous acid: moderately soluble |
DMSO: soluble 0.90-1.10 mg/mL, clear, colorless | |
ethanol: moderately soluble | |
H2O: moderately soluble | |
methanol: moderately soluble | |
storage temp. | 2-8°C |
Biochem/physiol Actions: | Studies have implicated that toyocamycin blocks the replication of fowl plague virus. |
Biochem/physiol Actions: | Toyocamycin is a nucleoside- type antibiotic analogue of adenosine, isolated from Streptomyces species. Toyocamycin is an anti-tumor antibiotic with various target activities. Toyocamycin is a potent inhibitor of RNA self-cleavage in mammalian cells. It also inhibits phosphatidylinositol kinase, a cell proliferation regulator. Toyocamycin was also found to inhibit Auxin signaling. Auxins are plant hormones with a crucial role in plant development regulation, and Toyocamycin was found to specifically inhibit auxin-responsive gene expression. |
Features and Benefits: | This compound is featured on the Adenosine Receptors ![]() ![]() |
Preparation Note: | Toyocamycin is soluble in DMSO at 0.90 - 1.10 mg/ml and yields a clear, colorless solution. It is also soluble in acidic solutions and is moderately soluble in water, methanol and ethanol. Solutions prepared in DMSO can be diluted 10-fold in water. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |