(+)-α-Tocopherol
SIGMA/T3634 - from vegetable oil, Type V, ~1000 IU/g
Synonym: 2,5,7,8-
CAS Number: 59-02-9
Empirical Formula (Hill Notation): C29H50O2
Molecular Weight: 430.71
EC Number: 200-412-2
MDL Number: MFCD00072045
Linear Formula: C29H50O2
Product Type: Chemical
| biological source | vegetable oil |
| bp | 200-220 °C/0.1 mmHg (lit.) |
| color | clear yellow to red |
| density | 0.95 g/mL at 25 °C (lit.) |
| form | viscous liquid |
| InChI | 1S/C29H50O2/c1-20(2)12-9- |
| InChI key | GVJHHUAWPYXKBD-IEOSBIPESA |
| Quality Level | 200  |
| refractive index | n |
| SMILES string | CC(C)CCC[C@@H](C)CCC[C@@H |
| specific activity | ~1000 IU/g |
| storage temp. | −20°C |
| type | Type V |
| Application: | (+)-α-Tocopherol has been used: • as a food supplement for juvenile cobia fish • to evaluate its protective effect on bisphenol A induced oxidative stress in rats • to test its chemopreventive efficacy in estrogen-mediated mammary cancer rats |
| Biochem/physiol Actions: | Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Various isofroms and analogues of tocopherol have opposing and differentiated regulatory activities in vivo. |
| Biochem/physiol Actions: | α-Tocopherol is essential for the photosynthesis in Synechocystis sp. strain PCC 6803. Supplementation with α-Tocopherol decreases lipid peroxidation and platelet aggregation. It inhibits protein kinase C and may play key role in gene regulation. |
| Caution: | Subject to air oxidation. |
| General description: | α-Tocopherol is synthesized from γ-tocopherol by the action of enzyme γ-tocopherol methyltransferase. It is the major form of Vitamin E in human plasma. It is present in sunflower seed oil. |
| Other Notes: | Mixed constitutional (α, β, γ, δ) isomers. |
| Packaging: | 10, 100 g in ampule |
| Packaging: | Packaged under argon in a sealed ampule. |
| Physical properties: | This product is miscible with chloroform or ethanol. It is practically insoluble in water but it is miscible with ether, acetone, and vegetable oils. It is unstable to alkaline conditions. |
| Quality: | Approx. 670 mg D-α-tocopherol per gram. The non-α content is typically between 5-35 mg/g |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | 230.0 °F - closed cup |
| Flash Point(C) | 110 °C - closed cup |
| activity | specific activity: ~1000 IU/g |
| bp | 200-220 °C/0.1 mmHg (lit.) |
| Density | 0.95 g/mL at 25 °C (lit.) |
| Refractive Index | n |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |