Triptolide

SIGMA/T3652 - from Tripterygium wilfordii, ≥98% (HPLC), solid

Synonym: PG 490

CAS Number: 38748-32-2
Empirical Formula (Hill Notation): C₂₀H₂₄O₆
Molecular Weight: 360.40
MDL Number: MFCD00210565
Linear Formula: C₂₀H₂₄O₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-T3652-1MG	1 mg	$206.00 1/EA	Add To Favorites
45-T3652-5MG	5 mg	$774.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T3652-1MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
biological source	Tripterygium wilfordii
color	white to off-white
form	solid
InChI	1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11?,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1
InChI key	DFBIRQPKNDILPW-KTGKZQHOSA-N
SMILES string	O=C1OCC2=C1CC[C@]3(C)[C@]4(O5)[C@@H]5[C@H]6[C@@](O6)(C(C)C)[C@@H](O)[C@]4(O7)[C@@H]7C[C@]32[H]
solubility	DMSO: soluble
storage temp.	2-8°C

Application:	Triptolide has been used as a NF-κB inhibitor to study the inhibition of cell invasion and angiogenesis in human thyroid cancer cells⁶. Triptolide has also been used to study its apoptotic effects in anaplastic thyroid cancer cells⁷.
Biochem/physiol Actions:	Triptolide is a diterpene triepoxide, the principal active ingredient in extracts from the Chinese herb Tripterygium wilfordii hook (TwHF). It is a potent immunosuppressant and anti-inflammatory. Triptolide has been shown to inhibit the expression of IL-2 in activated T cells at the level of purine-box/nuclear factor and NF-κB mediated transcription activation. It synergizes with cyclosporin A in promoting graft survival in animal models and in suppression of graft versus host disease in allogeneic bone marrow transplants. In addition, it induces apoptosis in tumor cells and potentiates tumor necrosis factor (TNF_α) induction of apoptosis in part through the suppression of c-IAP₂ and c-IAP₁ induction.
Packaging:	1, 5 mg in glass insert
Preparation Note:	Triptolide is soluble in DMSO. The stock solution should be stored in DMSO at -20 deg C after reconstitution.

Symbol	GHS06,GHS08
Signal word	Danger
Hazard statements	H300 + H330 - H361f
Precautionary statements	P202 - P260 - P264 - P270 - P271 - P304 + P340 + P310
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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