Synonym: 4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid; Arotinoid acid
CAS Number: 71441-28-6
Empirical Formula (Hill Notation): C24H28O2
Molecular Weight: 348.48
MDL Number: MFCD00673917
Linear Formula: C24H28O2
Product Type: Chemical
| InChI |
1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+ |
| InChI key |
FOIVPCKZDPCJJY-JQIJEIRASA-N |
| Quality Level |
200  |
| SMILES string |
CC(=C/c1ccc(cc1)C(O)=O)c2ccc3c(c2)C(C)(C)CCC3(C)C |
| solubility |
chloroform/methanol: soluble 9.80-10.20 mg/mL, clear, colorless to light yellow |
| |
DMSO: soluble 25 mM |
| |
ethanol: soluble 10 mM |
| storage temp. |
−20°C |
| Application: |
TTNPB has been used for transcriptional assays in 293T cells4. It has also been used as a RAR-agonist in cultured human cord blood CD34+CD38-lin- cells5. |
| Biochem/physiol Actions: |
Selective and highly potent retinoic acid analog with affinity for retinoic acid receptors (RAR) α, β, and γ, which are nuclear transcription factors. Produces ligand-activated transcription of genes that possess retinoic acid responsive elements. |
| Features and Benefits: |
This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: |
10 mg in poly bottle |
| Preparation Note: |
TTNPB dissolves in CHCL3/MeOH (1/1) at 9.80 - 10.20 mg/ml to yield a clear, colorless to light yellow solution. It is also soluble at 10 mM in ethanol and at 25 mM in DMSO. |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
GHS07,GHS08