Synonym: 4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid; Arotinoid acid
CAS Number: 71441-28-6
Empirical Formula (Hill Notation): C24H28O2
Molecular Weight: 348.48
MDL Number: MFCD00673917
Linear Formula: C24H28O2
Product Type: Chemical
InChI |
1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+ |
InChI key |
FOIVPCKZDPCJJY-JQIJEIRASA-N |
Quality Level |
200 ![External link](https://krackeler.com/images/sigma/ext-link.gif) |
SMILES string |
CC(=C/c1ccc(cc1)C(O)=O)c2ccc3c(c2)C(C)(C)CCC3(C)C |
solubility |
chloroform/methanol: soluble 9.80-10.20 mg/mL, clear, colorless to light yellow |
|
DMSO: soluble 25 mM |
|
ethanol: soluble 10 mM |
storage temp. |
−20°C |
Application: |
TTNPB has been used for transcriptional assays in 293T cells4. It has also been used as a RAR-agonist in cultured human cord blood CD34+CD38-lin- cells5. |
Biochem/physiol Actions: |
Selective and highly potent retinoic acid analog with affinity for retinoic acid receptors (RAR) α, β, and γ, which are nuclear transcription factors. Produces ligand-activated transcription of genes that possess retinoic acid responsive elements. |
Features and Benefits: |
This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
Other Notes: |
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. T3757.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin. ![External link](https://krackeler.com/images/sigma/ext-link.gif) |
Packaging: |
10 mg in poly bottle |
Preparation Note: |
TTNPB dissolves in CHCL3/MeOH (1/1) at 9.80 - 10.20 mg/ml to yield a clear, colorless to light yellow solution. It is also soluble at 10 mM in ethanol and at 25 mM in DMSO. |
Storage Temp. |
−20°C |
UNSPSC |
12352200 |