Advanced Search



3,3′,5,5′-Tetraiodothyroacetic acid

SIGMA/T3787

Synonym: 4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodobenzeneacetic acid; Tetrac

CAS Number: 67-30-1
Empirical Formula (Hill Notation): C14H8I4O4
Molecular Weight: 747.83
EC Number: 200-649-1
MDL Number: MFCD00055932
Linear Formula: C14H8O4I4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T3787-25MG 25 mg
 $138.00
1/EA		 Add To Favorites
45-T3787-100MG 100 mg
 $409.00
1/EA		 Add To Favorites

 

InChI 1S/C14H8I4O4/c15-8-4-7(5-9(16)13(8)21)22-14-10(17)1-6(2-11(14)18)3-12(19)20/h1-2,4-5,21H,3H2,(H,19,20)
InChI key PPJYSSNKSXAVDB-UHFFFAOYSA-N
Quality Level 200 
SMILES string OC(=O)Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1
solubility acetone: soluble 19.60-20.40 mg/mL, clear, colorless (or faintly yellow to yellow)
storage temp. −20°C
Application: 3,3′,5,5′-Tetraiodothyroacetic acid has been used:
• as a positive control to study the effects of ioxynil (IOX)
• diethylstilbestrol (DES) exposure on zebrafish embryos
• to study its effects on long-term potentiation (LTP) and long-term depression (LTD) in the dentate gyrus in urethane-anesthetized male rats
• to determine its influence on the actions of thyroid-stimulating hormone
• thyroid-stimulating immunoglobulins in orbital fibroblast
Biochem/physiol Actions: 3,3′,5,5′-Tetraiodothyroacetic acid (Tetrac) is a deaminated analog of L-thyroxine (T4). It prevents the pro-angiogenesis actions of T4 and 3,5,3′-triiodo-L-thyronine. It is a thyrointegrin receptor antagonist. Tetrac prevents the binding of thyroid hormones.
Biochem/physiol Actions: Studies in rats have reported that Tetrac may regulate TSH secretion under in vivo conditions1.
Linkage: Thyroid hormone analog
Preparation Note: 3,3′,5,5′-Tetraiodothyroacetic acid is soluble in acetone at 19.60 - 20.40 mg/ml and yields a clear, faint yellow to yellow solution.
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H300
Precautionary statements P264 - P301 + P310
Hazard Codes T+
Risk Statements 28
Safety Statements 45
RIDADR UN 2811 6.1 / PGI
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. −20°C
UNSPSC 12352200

The following items have been added to your cart:

Choose a favorite list for this item:
Catalog Number Description Price
$

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.


Quick Order

* Required


New Year Price Updates

We are currently working diligently to update our website pricing information for the New Year. If you place an order, you will be acknowledged with any corrected pricing. If you'd like the most current information sooner, please don't hesitate to drop us an email or give us a call and we'd be happy to assist. Thank you for your patience while we are updating.

800-334-7725
office@krackeler.com


Play Video

To Request a Quote

  1. Search or Browse for items and add to them to your Shopping Cart.
  2. Click the "Request Quote" button at the bottom of the Shopping Cart page.
  3. Fill out required fields.
  4. Optionally you can convert to standard checkout mode by choosing a payment type.
  5. Click "Request Quote" at the bottom of the page.

You will be contacted with a quote.

To Order From a Quote

  1. Register and login to the website.
  2. Receive a quote from your sales representative or customer service.
  3. Have your copy of the quote in hand.
  4. Visit our quote module to search for your quote.
Back to Top