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Triciribine hydrate

SIGMA/T3830 - ≥97% (HPLC)

Synonym: API-2; Akt/PKB Signaling Inhibitor-2; Inhibitor V; NSC 154020; TCN; VD-0002

CAS Number: 35943-35-2 (anhydrous)
Empirical Formula (Hill Notation): C13H16N6O4 · xH2O
Molecular Weight: 320.30 (anhydrous basis)
MDL Number: MFCD16879015
Linear Formula: C13H16N6O4 · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T3830-5MG 5 mg
 $274.00
1/EA		 Add To Favorites
45-T3830-25MG 25 mg
 $1120.00
1/EA		 Add To Favorites

 

assay ≥97% (HPLC)
color tan
form powder
InChI 1S/C13H16N6O4.H2O/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13;/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17);1H2/t6-,8-,9-,13-;/m1./s1
InChI key SPGRLWCWHWRPHX-DOKXERMVSA-N
Quality Level 100 
SMILES string O.Cn1nc(N)c2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c4ncnc1c24
solubility DMSO: >10 mg/mL
storage temp. 2-8°C
Application: Triciribine hydrate has been used to study the effect of diethyldithiocarbamate (DDC) on matrix metalloproteinase-1 (MMP-1) in hepatic stellate cells1. It has also been used to analyze ADAM 10 activation by (-)-epigallocatechin-3-gallate (EGCG) in N2a cells overexpressing Swedish mutant APP (SweAPP N2a cells)2.
Biochem/physiol Actions: Triciribine is a highly selective Akt/PKB inhibitor, that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3.
Features and Benefits: This compound is featured on the PKB/Akt  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Preparation Note: Triciribine hydrate is soluble in DMSO at a concentration that is greater than 10 mg/ml.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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