Anti-β-Tubulin III antibody produced in rabbit
SIGMA/T3952 - ~1 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym: Anti-Tuj 1
MDL Number: MFCD01323870
Product Type: Chemical
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen ~50 kDa |
| Quality Level | 200  |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| technique(s) | western blot: 1:500-1:1,000 |
| UniProt accession no. | Q13509  |
| Application: | Anti-β-Tubulin III antibody is suitable for use in flow cytometry (1:200-1:500), immunohistochemistry (1:100-1:200), immunoblot (approx. 50kDa) and western blot (1:500-1:1,000). |
| Application: | Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below. Immunocytochemistry (1 paper) Immunofluorescence (1 paper) Western Blotting (1 paper) |
| Biochem/physiol Actions: | Missense mutations in the tubulin β 3 class III gene (TUBB3) impacts microtubule organisation in neuronal cells and contributes to neurological disorders. Mutations in TUBB3 is implicated in tubulopathies contributing to malformations in developing fetus. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Microtubules are heterodimeric proteins that comprise of α- and β-tubulins. β-tubulins have several different isotypes . β-Tubulin III is a marker for nerve cell differentiation, as well as for venous and lymphatic valves . Changes in β-tubulin III expression have been associated with medulloblastoma Anti-tubulin antibodies are useful to study the localization of tubulin proteins. Anti-β-Tubulin III antibody is specific for β-Tubulin III in humans. |
| General description: | Tubulin β 3 class III (TUBB3) is mapped to human chromosome 16q24.3. |
| Immunogen: | synthetic peptide corresponding to residues 151-165 of human β-Tubulin III. |
| Physical form: | solution in phosphate buffered saline, containing 0.02% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |