Tobramycin

SIGMA/T4014 - Aminoglycoside antibiotic

Synonym: 3′-Deoxykanamycin B; Nebramycin Factor 6; O-[3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)]-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribohexopyranosyl-(1→4)]-2-deoxy-D-streptamine

CAS Number: 32986-56-4
Empirical Formula (Hill Notation): C₁₈H₃₇N₅O₉
Molecular Weight: 467.51
EC Number: 251-322-5
MDL Number: MFCD00077885
Linear Formula: C₁₈H₃₇N₅O₉
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-T4014-100MG	100 mg	$107.00 1/EA	Add To Favorites
45-T4014-500MG	500 mg	$446.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T4014-100MG

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-negative bacteria
biological source	Streptomyces tenebrarius
color	white to off-white
concentration	≥900 μg/mg (anhydrous)
form	powder
InChI	1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11+,12+,13+,14-,15+,16-,17+,18+/m0/s1
InChI key	NLVFBUXFDBBNBW-SNGYORCQSA-N
mode of action	protein synthesis \| interferes
Quality Level	200
SMILES string	NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O
storage condition	(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
storage temp.	2-8°C

Application:	Tobramycin has been used: • to study the effect of tobramycin on bacteriophage infected biofilms • to study the effects of antibiotics on Pseudomonas aeruginosa strain • as a comparator antibiotic
Biochem/physiol Actions:	Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial membranes by binding to 16S rRNA (ribosomal RNA). It inhibits translocation and elicits miscoding. Tobramycin is used to treat Pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis, and other soft-tissue infections. It is a potential therapy for sinus infections.
Biochem/physiol Actions:	Tobramycin is an aminoglycoside. Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding. Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.
General description:	Chemical structure: aminoglycoside
General description:	Tobramycin is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the Pseudomonas species.
Other Notes:	Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
Packaging:	100, 500 mg in glass bottle

Symbol	GHS08
Signal word	Warning
Hazard statements	H361f
Precautionary statements	P201 - P202 - P280 - P308 + P313 - P405 - P501
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Storage Temp.	2-8°C
UNSPSC	51101500

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