6, 2′, 4′-trimethoxyflavone
SIGMA/T4080 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 720675-90-1
Empirical Formula (Hill Notation): C18H16O5
Molecular Weight: 312.32
MDL Number: MFCD03412381
Linear Formula: C18H16O5
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | yellow |
| form | powder |
| InChI | 1S/C18H16O5/c1-20-11-5-7- |
| InChI key | WUWFDVDASNSUKP-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | COc1ccc(c(OC)c1)C2=CC(=O) |
| solubility | DMSO: >5 mg/mL |
| storage condition | desiccated |
| protect from light | |
| storage temp. | room temp |
| Biochem/physiol Actions: | 6, 2′, 4′-trimethoxyflavone is a selective aryl hydrocarbon receptor (AHR) antagonist with no partial agonist activity. The role of the transcription factor aryl hydrocarbon receptor (AHR) in biology is still under evaluation and has expanded beyond that of a xenobiotic sensor and regulator of detoxification. Inhibition of AHR activity by antagonists could result in anti-inflammatory actions. 6, 2′, 4′-trimethoxyflavone (TMF) is a pure AHR antagonist. The compound compete with agonists, such as 2, 3, 7, 8-tetrachlorodibenzo-p-di |
| Biochem/physiol Actions: | The AHR along with immune functions, is also associated with endocrine processes and cancer development. |
| Packaging: | 10, 50 mg in glass bottle |
| Preparation Note: | 6, 2′, 4′-trimethoxyflavone is soluble in DMSO at a concentration that is greater than 5 mg/ml. |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301 + P310 |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |