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Triamterene

SIGMA/T4143 - ≥99%

Synonym: 2,4,7-Triamino-6-phenylpteridine; 6-Phenyl-2,4,7-pteridinetriamine

CAS Number: 396-01-0
Empirical Formula (Hill Notation): C12H11N7
Molecular Weight: 253.26
EC Number: 206-904-3
MDL Number: MFCD00006708
Linear Formula: C12H11N7
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T4143-10G 10 g
 $90.50
1/EA		 Add To Favorites
45-T4143-25G 25 g
 $201.00
1/EA		 Add To Favorites

 

assay ≥99%
InChI 1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)
InChI key FNYLWPVRPXGIIP-UHFFFAOYSA-N
originator Wellspring
Quality Level 100 
SMILES string Nc1nc(N)c2nc(-c3ccccc3)c(N)nc2n1
solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 1.2 mg/mL
  DMSO: soluble 5.4 mg/mL
  H2O: insoluble
Application: Triamterene has been used to study its effects on urokinase receptor (uPAR) induction in podocytes under in vitro conditions2. Triamterene has also been identified as an activator compound from a LOPAC library screen using a fluorogenic α-glucosidase assay3.
Biochem/physiol Actions: Weak diuretic with potassium sparing properties; blocks Na+ reuptake in the kidneys.
Features and Benefits: This compound was developed by Wellspring . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Preparation Note: 200 mg of triamterene is soluble in 4 ml of warm formic acid and yields a clear, yellow-green solution. Triamterene is also soluble in DMSO (5.4 mg/ml), and in 45% (w/v) aqueous 2-hydroxypropyl-β-cyclodextrin (1.2 mg/ml). However, it is insoluble in water.
Purity ≥99%
UNSPSC 12352200

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