Tyrphostin AG 1478

SIGMA/T4182 - ≥98%

Synonym: N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine

CAS Number: 175178-82-2
Empirical Formula (Hill Notation): C₁₆H₁₄ClN₃O₂
Molecular Weight: 315.75
MDL Number: MFCD00270914
Linear Formula: C₁₆H₁₄ClN₃O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-T4182-1MG	1 mg	$76.20 1/EA		Add To Favorites
45-T4182-5MG	5 mg	$228.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98%
form	solid
InChI	1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
InChI key	GFNNBHLJANVSQV-UHFFFAOYSA-N
Quality Level	100
SMILES string	COc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OC
solubility	0.1 M HCl: soluble <0.4 mg/mL
	0.1 M NaOH: insoluble
	2-hydroxypropyl-β-cyclodextrin: insoluble
	DMSO:methanol (1:1): soluble 10 mg/mL, clear, colorless
	ethanol: soluble 10 mg/mL
	H₂O: insoluble
	methylene chloride: soluble 10 mg/mL
storage temp.	2-8°C

Application:	Tyrphostin AG 1478 has been used as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor to study its effect on desmoid cell mobility in boyden chamber motility assays. It has also been used to inhibit phosphorylation of c-Met by exogenous transforming growth factor α in epidermoid carcinoma cell line A431.
Biochem/physiol Actions:	Selective inhibitor of epidermal growth factor receptor protein
Biochem/physiol Actions:	Tyrphostin AG 1478 is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. It contributes to the development of hypomagnesemia and cardiac dysfunction in rats. Tyrphostin AG 1478 acts as a potential therapeutic agent for breast cancer.
Features and Benefits:	This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound is featured on the EGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	1, 5 mg in ampule
Preparation Note:	Tyrphostin AG 1478 dissolves in DMSO:MeOH (1:1) at 10 mg/ml to yield a clear, colorless solution. It is also soluble in methylene chloride (10 mg/ml), ethanol (10 mg/ml) and 0.1 N HCl (less than 0.4 mg/ml). However, it is insoluble in water, 2-hydroxypropyl-β-cyclodextrin, and 0.1 N NaOH.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98%
Storage Temp.	2-8°C
UNSPSC	12352200

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