Tyrphostin AG 1478
SIGMA/T4182 - ≥98%
Synonym: N-
CAS Number: 175178-82-2
Empirical Formula (Hill Notation): C16H14ClN3O2
Molecular Weight: 315.75
MDL Number: MFCD00270914
Linear Formula: C16H14ClN3O2
Product Type: Chemical
assay | ≥98% |
form | solid |
InChI | 1S/C16H14ClN3O2/c1-21-14- |
InChI key | GFNNBHLJANVSQV-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | COc1cc2ncnc(Nc3cccc(Cl)c3 |
solubility | 0.1 M HCl: soluble <0.4 mg/mL |
0.1 M NaOH: insoluble | |
2-hydroxypropyl-β-cyclode |
|
DMSO:methanol (1:1): soluble 10 mg/mL, clear, colorless | |
ethanol: soluble 10 mg/mL | |
H2O: insoluble | |
methylene chloride: soluble 10 mg/mL | |
storage temp. | 2-8°C |
Application: | Tyrphostin AG 1478 has been used as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor to study its effect on desmoid cell mobility in boyden chamber motility assays. It has also been used to inhibit phosphorylation of c-Met by exogenous transforming growth factor α in epidermoid carcinoma cell line A431. |
Biochem/physiol Actions: | Selective inhibitor of epidermal growth factor receptor protein |
Biochem/physiol Actions: | Tyrphostin AG 1478 is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. It contributes to the development of hypomagnesemia and cardiac dysfunction in rats. Tyrphostin AG 1478 acts as a potential therapeutic agent for breast cancer. |
Features and Benefits: | This compound is a featured product for Kinase Phosphatase Biology research. Click here ![]() ![]() |
Features and Benefits: | This compound is featured on the EGFR ![]() ![]() |
Packaging: | 1, 5 mg in ampule |
Preparation Note: | Tyrphostin AG 1478 dissolves in DMSO:MeOH (1:1) at 10 mg/ml to yield a clear, colorless solution. It is also soluble in methylene chloride (10 mg/ml), ethanol (10 mg/ml) and 0.1 N HCl (less than 0.4 mg/ml). However, it is insoluble in water, 2-hydroxypropyl-β-cyclode |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |