apo-Transferrin human
SIGMA/T4382 - powder, ≥98% (agarose gel electrophoresis)
Synonym: Human transferrin; Siderophilin
CAS Number: 11096-37-0
EC Number: 234-318-8
MDL Number: MFCD00130536
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T4382-100MG
| assay | ≥98% (agarose gel electrophoresis) |
| biological source | human |
| form | powder |
| impurities | HIV and HBsAg, source material tested negative |
| Iron content | ≤0.005% |
| mol wt | 76-81 kDa |
| Quality Level | 200  |
| shipped in | wet ice |
| solubility | H2O: 50 mg/mL |
| storage temp. | −20°C |
| technique(s) | cell culture | mammalian: suitable |
| UniProt accession no. | P02787  |
| Application: | Apo-Transferrin human has been used: • to determine the competitive binding of bismuth to albumin and transferrin by fast performance liquid chromatography (FPLC) • to study titanium-transferrin complex by electrochemical method • in the preparation of transferrin solution and in the formation of conjugates with ruthenium-complexes for cellular viability studies |
| Biochem/physiol Actions: | Apo-transferrin is an iron transport protein. The concentration of transferrin in blood plasma is about 35 μM. Transferrin also functions in the transport of therapeutic, diagnostic and toxic ions like Ga3+, Ru3+ and Al3+. Polymorphism in TF gene has pathological implications in Parkinson′s disease. |
| Biochem/physiol Actions: | Apo-transferrin is required for the survival and differentiation of oligodendroglial cells. |
| General description: | Apo-transferrin human is a glycoprotein, possessing homologous carboxyl and amino domain. Both the domain binds to one molecule of iron. Only 30% of transferrin is saturated with iron in the amino domain. Apo-transferrin in human is encoded by the gene TF which is localized on human chromosome 3q22.1. |
| Linkage: | Similar to T 2252 |
| Other Notes: | Non-heme iron-transport protein. |
| Packaging: | 1 g in glass bottle |
| Packaging: | 100, 500 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Purity | ≥98% (agarose gel electrophoresis) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |