(6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride
SIGMA/T4425
Synonym: (6R)-BH4
CAS Number: 69056-38-8
Empirical Formula (Hill Notation): C9H15N5O3 · 2HCl
Molecular Weight: 314.17
MDL Number: MFCD00891665
Linear Formula: C9H15N5O3 · 2HCl
Product Type: Chemical
InChI | 1S/C9H15N5O3.2ClH/c1-3(15 |
InChI key | RKSUYBCOVNCALL-NTVURLEBSA |
Quality Level | 200 ![]() |
SMILES string | Cl.Cl.C[C@H](O)[C@H](O)[C |
solubility | water, oxygen free: soluble 19.60-20.40 mg/mL, clear to slightly hazy, colorless to faintly yellow |
storage temp. | −20°C |
Application: | (6R)-BH4 has been used as a buffer component for assaying tyrosine hydroxylase enzyme activity in mouse brain tissues. (6R)-BH4 has also been identified as an activator compound from a LOPAC library screen using a fluorogenic α-glucosidase assay. |
Biochem/physiol Actions: | Lack of tetrahydrobiopterin may cause hyperphenylalaninemia. Diseases like, Parkinson′s, autism, depression and Alzheimer′s shows low concentration of tetrahydrobiopterin in the cerebrospinal fluid. This coenzyme participates in dopamine (DA) synthesis. |
Features and Benefits: | This compound is featured on the Dopamine, Norepinephrine and Epinephrine Synthesis ![]() ![]() ![]() |
General description: | Tetrahydrobiopterin is a natural cofactor for phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthase and alkylglycerol monooxygenase. |
Packaging: | 5, 25, 100 mg in glass bottle |
Preparation Note: | (6R)-5,6,7,8-Tetrahydrobi |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H302 |
Hazard Codes | Xn |
Risk Statements | 22 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | −20°C |
UNSPSC | 12352200 |