(6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride

SIGMA/T4425

Synonym: (6R)-BH₄

CAS Number: 69056-38-8
Empirical Formula (Hill Notation): C₉H₁₅N₅O₃ · 2HCl
Molecular Weight: 314.17
MDL Number: MFCD00891665
Linear Formula: C₉H₁₅N₅O₃ · 2HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-T4425-5MG	5 mg	$92.70 1/EA	Add To Favorites
45-T4425-25MG	25 mg	$306.00 1/EA	Add To Favorites
45-T4425-100MG	100 mg	$1010.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T4425-100MG

Properties
Descriptions
Safety Info.
Basic Data

InChI	1S/C9H15N5O3.2ClH/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7;;/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17);2*1H/t3-,4+,6-;;/m0../s1
InChI key	RKSUYBCOVNCALL-NTVURLEBSA-N
Quality Level	200
SMILES string	Cl.Cl.C[C@H](O)[C@H](O)[C@H]1CNC2=C(N1)C(=O)NC(N)=N2
solubility	water, oxygen free: soluble 19.60-20.40 mg/mL, clear to slightly hazy, colorless to faintly yellow
storage temp.	−20°C

Application:	(6R)-BH₄ has been used as a buffer component for assaying tyrosine hydroxylase enzyme activity in mouse brain tissues. (6R)-BH₄ has also been identified as an activator compound from a LOPAC library screen using a fluorogenic α-glucosidase assay.
Biochem/physiol Actions:	Lack of tetrahydrobiopterin may cause hyperphenylalaninemia. Diseases like, Parkinson′s, autism, depression and Alzheimer′s shows low concentration of tetrahydrobiopterin in the cerebrospinal fluid. This coenzyme participates in dopamine (DA) synthesis.
Features and Benefits:	This compound is featured on the Dopamine, Norepinephrine and Epinephrine Synthesis and Nitric Oxide Synthases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description:	Tetrahydrobiopterin is a natural cofactor for phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthase and alkylglycerol monooxygenase.
Packaging:	5, 25, 100 mg in glass bottle
Preparation Note:	(6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride ((6R)-BH₄ ) is soluble in oxygen free water at 19.60 - 20.40 mg/ml and yields a clear to slightly hazy, colorless to faint yellow solution.

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	−20°C
UNSPSC	12352200

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