N_α-p-Tosyl-L-arginine methyl ester hydrochloride

SIGMA/T4626

Synonym: TAME hydrochloride

CAS Number: 1784-03-8
Empirical Formula (Hill Notation): C₁₄H₂₂N₄O₄S · HCl
Molecular Weight: 378.87
EC Number: 217-235-1
MDL Number: MFCD00012578
Linear Formula: H₂NC(=NH)NH(CH₂)₃CH(NHSO₂C₆H₄CH₃)CO₂CH₃· HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-T4626-5G	5 g	$70.00 1/EA	Add To Favorites
45-T4626-25G	25 g	$292.00 1/EA	Add To Favorites
45-T4626-100G	100 g	$680.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (TLC)
color	white
form	powder
InChI	1S/C14H22N4O4S.ClH/c1-10-5-7-11(8-6-10)23(20,21)18-12(13(19)22-2)4-3-9-17-14(15)16;/h5-8,12,18H,3-4,9H2,1-2H3,(H4,15,16,17);1H/t12-;/m0./s1
InChI key	JIQFFACVQXXHMY-YDALLXLXSA-N
mp	145-147 (lit.)
Quality Level	200
SMILES string	Cl.COC(=O)[C@H](CCCNC(N)=N)NS(=O)(=O)c1ccc(C)cc1
storage temp.	−20°C
technique(s)	ligand binding assay: suitable

Application:	Nα-p-Tosyl-L-arginine methyl ester hydrochloride has been used as an esterolytic substrate to assess trypsin-like activity in midgut extracts. It has also been used as a substrate for measuring trypsin activity of pancreatin and human intestinal samples.
Biochem/physiol Actions:	N_α-p-Tosyl-L-arginine methyl ester (TAME) binds to anaphase-promoting complex (APC) and prevents its activation by Cdc20 and Cdh1.
General description:	Substrate for trypsin, thrombin, plasmin, and other proteases.
Packaging:	5, 25, 100 g in poly bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (TLC)
mp	145-147 (lit.)
Storage Temp.	−20°C
UNSPSC	12352103

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