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Tanshinone IIA

SIGMA/T4952 - ≥97% (HPLC)

Synonym: 1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione; Dan Shen ketone

CAS Number: 568-72-9
Empirical Formula (Hill Notation): C19H18O3
Molecular Weight: 294.34
MDL Number: MFCD00238692
Linear Formula: C19H18O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T4952-5MG 5 mg
 $165.00
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45-T4952-25MG 25 mg
 $563.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: T4952-25MG

 

application(s) metabolomics
vitamins, nutraceuticals, and natural products
assay ≥97% (HPLC)
color orange to dark red
form powder
InChI 1S/C19H18O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,9H,4-5,8H2,1-3H3
InChI key HYXITZLLTYIPOF-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cc1coc2-c3ccc4c(CCCC4(C)C)c3C(=O)C(=O)c12
solubility methanol: 5 mg/mL, clear, red-orange to red
storage temp. 2-8°C
Application: Tanshinone IIA has been used:
• to test its effect on osteoclast differentiation in ovariectomy-induced osteoporosis mouse model
• to test its effects on microglia and to study its neuroprotective effect on ischemia-reperfusion injured rat brain
• to study its effects on the proliferation, apoptosis, and autophagy of acute myeloid leukemia (AML) in vitro and in vivo models
• to investigate its anti-inflammatory and protective effects on ATDC5 cells from lipopolysaccharide (LPS)-induced inflammatory injury
Biochem/physiol Actions: Phenanthrenequinone constituent of Chinese medicinal herb Danshen (Salvia miltiorrhiza). Anti-inflammatory. Antioxidant. Cytotoxic against a variety of cell lines, inlcuding human glioma cells.
Biochem/physiol Actions: Tanshinone IIA provides protective effects against cardiovascular diseases by enhancing angiogenesis. It elicits neuroprotective, anti-cancer, anti-diabetic, and anti-obesity properties. Tan-IIA plays a significant role in modulating the development and function of immune cells.
General description: Tanshinone IIA (Tan IIA) is a natural diterpene quinone, a lipophilic component derived from the root extract of Salvia miltiorrhiza.
Packaging: 25 mg in poly bottle
Packaging: 5 mg in glass insert
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352212

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