Tanshinone IIA

SIGMA/T4952 - ≥97% (HPLC)

Synonym: 1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione; Dan Shen ketone

CAS Number: 568-72-9
Empirical Formula (Hill Notation): C₁₉H₁₈O₃
Molecular Weight: 294.34
MDL Number: MFCD00238692
Linear Formula: C₁₉H₁₈O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-T4952-5MG	5 mg	$151.00 1/EA	Add To Favorites
45-T4952-25MG	25 mg	$514.00 1/EA	Add To Favorites

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This image depicts SKU: T4952-25MG

Properties
Descriptions
Safety Info.
Basic Data

application(s)	metabolomics vitamins, nutraceuticals, and natural products
assay	≥97% (HPLC)
color	orange to dark red
form	powder
InChI	1S/C19H18O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,9H,4-5,8H2,1-3H3
InChI key	HYXITZLLTYIPOF-UHFFFAOYSA-N
Quality Level	100
SMILES string	Cc1coc2-c3ccc4c(CCCC4(C)C)c3C(=O)C(=O)c12
solubility	methanol: 5 mg/mL, clear, red-orange to red
storage temp.	2-8°C

Application:	Tanshinone IIA has been used: • to test its effect on osteoclast differentiation in ovariectomy-induced osteoporosis mouse model • to test its effects on microglia and to study its neuroprotective effect on ischemia-reperfusion injured rat brain • to study its effects on the proliferation, apoptosis, and autophagy of acute myeloid leukemia (AML) in vitro and in vivo models • to investigate its anti-inflammatory and protective effects on ATDC5 cells from lipopolysaccharide (LPS)-induced inflammatory injury
Biochem/physiol Actions:	Phenanthrenequinone constituent of Chinese medicinal herb Danshen (Salvia miltiorrhiza). Anti-inflammatory. Antioxidant. Cytotoxic against a variety of cell lines, inlcuding human glioma cells.
Biochem/physiol Actions:	Tanshinone IIA provides protective effects against cardiovascular diseases by enhancing angiogenesis. It elicits neuroprotective, anti-cancer, anti-diabetic, and anti-obesity properties. Tan-IIA plays a significant role in modulating the development and function of immune cells.
General description:	Tanshinone IIA (Tan IIA) is a natural diterpene quinone, a lipophilic component derived from the root extract of Salvia miltiorrhiza.
Packaging:	25 mg in poly bottle
Packaging:	5 mg in glass insert

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352212

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