Triparanol

SIGMA/T5200 - ≥97% (HPLC), powder

Synonym: 1-(4-(2-Diethylaminoethoxy)phenyl)-1-p-tolyl-2-(4-chlorophenyl)ethanol

CAS Number: 78-41-1
Empirical Formula (Hill Notation): C₂₇H₃₂NO₂Cl
Molecular Weight: 438.00
EC Number: 201-115-0
MDL Number: MFCD00865748
Linear Formula: C₂₇H₃₂NO₂Cl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-T5200-5MG	5 mg	$214.00 1/EA	Add To Favorites
45-T5200-25MG	25 mg	$781.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (HPLC)
color	white to off-white
form	powder
InChI	1S/C27H32ClNO2/c1-4-29(5-2)18-19-31-26-16-12-24(13-17-26)27(30,23-10-6-21(3)7-11-23)20-22-8-14-25(28)15-9-22/h6-17,30H,4-5,18-20H2,1-3H3
InChI key	SYHDSBBKRLVLFF-UHFFFAOYSA-N
mp	102.9-103.7 °C
Quality Level	100
SMILES string	CCN(CC)CCOc1ccc(cc1)C(O)(Cc2ccc(Cl)cc2)c3ccc(C)cc3
solubility	alcohol: soluble
	DMSO: 20 mg/mL
	H₂O: insoluble
	olive oil: slightly soluble
storage temp.	2-8°C

Application:	Triparanol has been used to inhibit cholesterol biosynthesis in lipid rafts¹. Triparanol has also been used as a 3β-hydroxysterol-Δ24-reductase inhibitor to study its effect on delayed-rectifier potassium current (I_ks) channels².
Biochem/physiol Actions:	Desmosterol Delta24 (D24) reductase inhibitor.
Biochem/physiol Actions:	Triparanol is known to repress Hedgehog signaling in cancer cells and can also inhibit tumor growth³.
Packaging:	5, 25 mg in glass bottle
Preparation Note:	Triparanol is soluble in DMSO at 20 mg/ml and is also soluble in alcohol. It is slightly soluble in olive oil and is insoluble in water.

Symbol	GHS05,GHS07
Signal word	Danger
Hazard statements	H302 - H318
Precautionary statements	P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310
Hazard Codes	Xn
Risk Statements	22-41
Safety Statements	26-39
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
mp	102.9-103.7 °C
Storage Temp.	2-8°C
UNSPSC	12352200

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