Tyrphostin AG 825
SIGMA/T5443 - ≥92.5%
Synonym: 5-
CAS Number: 149092-50-2
Empirical Formula (Hill Notation): C19H15N3O3S2
Molecular Weight: 397.47
MDL Number: MFCD01074971
Linear Formula: C19H15N3O3S2
Product Type: Chemical
assay | ≥92.5% |
form | powder |
InChI | 1S/C19H15N3O3S2/c1-25-15- |
InChI key | KXDONFLNGBQLTN-WUXMJOGZSA |
Quality Level | 200 ![]() |
SMILES string | COc1cc(cc(CSc2nc3ccccc3s2 |
solubility | DMSO: soluble |
methanol: soluble | |
storage temp. | −20°C |
Application: | Tyrphostin AG 825 has been used to study its effects on iodide uptake in EMT6 cells1. |
Biochem/physiol Actions: | EGF receptor tyrosine kinase inhibitor, inactive against IGF-1 Receptor. |
Biochem/physiol Actions: | Tyrphostin AG 825 has been used in combination with hypericin-mediated photodynamic therapy (HY-PDT) for evaluating its therapeutic effects in HER2 overexpressing human breast cancer cells. This study reported that AG 825 combination increased the induction of cell death, HER2 degradation and inhibited colony formation in cancer cells2. |
Features and Benefits: | This compound is a featured product for Kinase Phosphatase Biology research. Click here ![]() ![]() |
Preparation Note: | Tyrphostin AG 825 is soluble in DMSO and methanol. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥92.5% |
Storage Temp. | −20°C |
UNSPSC | 12352200 |