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Tyrphostin AG 825

SIGMA/T5443 - ≥92.5%

Synonym: 5-[(Benzothiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzylidenecyanoacetamide; Tyrphostin C15

CAS Number: 149092-50-2
Empirical Formula (Hill Notation): C19H15N3O3S2
Molecular Weight: 397.47
MDL Number: MFCD01074971
Linear Formula: C19H15N3O3S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T5443-2MG 2 mg
 $132.00
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assay ≥92.5%
form powder
InChI 1S/C19H15N3O3S2/c1-25-15-8-11(6-12(9-20)18(21)24)7-13(17(15)23)10-26-19-22-14-4-2-3-5-16(14)27-19/h2-8,23H,10H2,1H3,(H2,21,24)/b12-6+
InChI key KXDONFLNGBQLTN-WUXMJOGZSA-N
Quality Level 200 
SMILES string COc1cc(cc(CSc2nc3ccccc3s2)c1O)C=C(/C#N)C(N)=O
solubility DMSO: soluble
  methanol: soluble
storage temp. −20°C
Application: Tyrphostin AG 825 has been used to study its effects on iodide uptake in EMT6 cells1.
Biochem/physiol Actions: EGF receptor tyrosine kinase inhibitor, inactive against IGF-1 Receptor.
Biochem/physiol Actions: Tyrphostin AG 825 has been used in combination with hypericin-mediated photodynamic therapy (HY-PDT) for evaluating its therapeutic effects in HER2 overexpressing human breast cancer cells. This study reported that AG 825 combination increased the induction of cell death, HER2 degradation and inhibited colony formation in cancer cells2.
Features and Benefits: This compound is a featured product for Kinase Phosphatase Biology research. Click here  to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Preparation Note: Tyrphostin AG 825 is soluble in DMSO and methanol.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥92.5%
Storage Temp. −20°C
UNSPSC 12352200

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