TG003

SIGMA/T5575 - ≥98% (HPLC)

Synonym: (Z)-1-(3-Ethyl-5-methoxy-2,3-dihydrobenzothiazol-2-ylidene)propan-2-one

CAS Number: 300801-52-9
Empirical Formula (Hill Notation): C₁₃H₁₅NO₂S
Molecular Weight: 249.33
MDL Number: MFCD00624584
Linear Formula: C₁₃H₁₅NO₂S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-T5575-5MG	5 mg	$196.00 1/EA		Add To Favorites
45-T5575-25MG	25 mg	$778.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C13H15NO2S/c1-4-14-11-8-10(16-3)5-6-12(11)17-13(14)7-9(2)15/h5-8H,4H2,1-3H3/b13-7-
InChI key	BGVLELSCIHASRV-QPEQYQDCSA-N
mp	132-132.5 °C
Quality Level	100
SMILES string	CCN1C(Sc2ccc(OC)cc12)=CC(C)=O
solubility	DMSO: 33 mg/mL
storage temp.	2-8°C

Application:	TG003 has been used in PAC1 cell culture and in vitro kinase assays.
Application:	TG003 has been used to develop assays for screening substances that affect mRNA splicing¹.
Biochem/physiol Actions:	Potent, specific, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (Clk). K_i = 10 nM for mClk1/Sty; IC₅₀ = 15 nM, 20 nM, 200 nM, and > 10 mM for mClk4, mClk1, mClk2, and mClk3, respectively.
Biochem/physiol Actions:	TG003 regulates alternative splicing and reduces the phosphorylation of SF2/ASF1.
Biochem/physiol Actions:	TG003, a CLK (cdc2-like kinase) family inhibitor is used as a drug for duchenne muscular dystrophy.
Packaging:	5, 25 mg in glass bottle
Packaging:	Packaged under nitrogen.
Preparation Note:	TG003 is soluble in DMSO at 33 mg/ml.

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	≥98% (HPLC)
mp	132-132.5 °C
Storage Temp.	2-8°C
UNSPSC	12352200

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