TG003
SIGMA/T5575 - ≥98% (HPLC)
Synonym: (Z)
CAS Number: 300801-52-9
Empirical Formula (Hill Notation): C13H15NO2S
Molecular Weight: 249.33
MDL Number: MFCD00624584
Linear Formula: C13H15NO2S
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C13H15NO2S/c1-4-14-11- |
InChI key | BGVLELSCIHASRV-QPEQYQDCSA |
mp | 132-132.5 °C |
Quality Level | 100 ![]() |
SMILES string | CCN1C(Sc2ccc(OC)cc12)=C |
solubility | DMSO: 33 mg/mL |
storage temp. | 2-8°C |
Application: | TG003 has been used in PAC1 cell culture and in vitro kinase assays. |
Application: | TG003 has been used to develop assays for screening substances that affect mRNA splicing1. |
Biochem/physiol Actions: | Potent, specific, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (Clk). Ki = 10 nM for mClk1/Sty; IC50 = 15 nM, 20 nM, 200 nM, and > 10 mM for mClk4, mClk1, mClk2, and mClk3, respectively. |
Biochem/physiol Actions: | TG003 regulates alternative splicing and reduces the phosphorylation of SF2/ASF1. |
Biochem/physiol Actions: | TG003, a CLK (cdc2-like kinase) family inhibitor is used as a drug for duchenne muscular dystrophy. |
Packaging: | 5, 25 mg in glass bottle |
Packaging: | Packaged under nitrogen. |
Preparation Note: | TG003 is soluble in DMSO at 33 mg/ml. |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 26-36 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Purity | ≥98% (HPLC) |
mp | 132-132.5 °C |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |