TMPH hydrochloride

SIGMA/T5576 - solid, (Product is pure based on CHN, NMR and MS results)

Synonym: 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate hydrochloride

CAS Number: 849461-91-2
Empirical Formula (Hill Notation): C₁₆H₃₂ClNO₂
Molecular Weight: 305.88
MDL Number: MFCD08277030
Linear Formula: C₁₆H₃₂ClNO₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-T5576-5MG	5 mg	$228.00 1/EA		Add To Favorites
45-T5576-25MG	25 mg	$0.00 1/EA CALL FOR PRICE		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

color	white
form	solid
InChI	1S/C16H31NO2.ClH/c1-6-7-8-9-10-14(18)19-13-11-15(2,3)17-16(4,5)12-13;/h13,17H,6-12H2,1-5H3;1H
InChI key	XIDDVJIJIFWGIX-UHFFFAOYSA-N
Quality Level	100
SMILES string	Cl.CCCCCCC(=O)OC1CC(C)(C)NC(C)(C)C1
solubility	H₂O: 22 mg/mL at ~60 °C
storage condition	under inert gas
storage temp.	2-8°C

Application:	Studies using TMPH have reported that it can alleviate the seizure-causing effect of levamisole. Additionally, it has been reported that TMPH does not induce behavioral changes in mice¹.
Biochem/physiol Actions:	2,2,6,6-tetramethylpiperidin-4-yl heptanoate (TMPH) is a potent inhibitor of neuronal nicotinic receptors. Evaluation of nicotinic acetylcholine receptor (nAChR) subunits expressed in Xenopus laevis oocytes indicated that TMPH can produce a potent and long-lasting inhibition of neuronal nAChR formed by the pairwise combination of the most abundant neuronal alpha (i.e., alpha3 and alpha4) and beta subunits (beta2 and beta4), with relatively little effect, because of rapid reversibility of inhibition, on muscle-type (alpha1beta1gammadelta) or alpha7 receptors. However, the inhibition of neuronal beta subunit-containing receptors was also decreased if any of the nonessential subunits alpha5, alpha6, or beta3 were coexpressed. This decrease in inhibition is shown to be associated with a single amino acid present in the second transmembrane domain of these subunits. TMPH abilitty to relate the diverse central nervous system effects to specific nAChR subtypes makes it a useful tool for studying the functional roles of nAChR.
Features and Benefits:	This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5, 25 mg in glass bottle
Preparation Note:	TMPH hydrochloride is soluble in water at 22 mg/ml (at approx. 60° C).

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H317 - H319 - H335
Precautionary statements	P280 - P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38-43
Safety Statements	26-36/37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	12352200

Choose a favorite list for this item:

Catalog Number	Description	Price

		$

Please choose a list :

Continue Shopping

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.