(±)-α-Lipoic acid
SIGMA/T5625 - synthetic, ≥99% (titration), powder
Synonym: (±)
CAS Number: 1077-28-7
Empirical Formula (Hill Notation): C8H14O2S2
Molecular Weight: 206.33
EC Number: 214-071-2
MDL Number: MFCD00005474
Linear Formula: C8H14O2S2
Product Type: Chemical
assay | ≥99% (titration) |
biological source | synthetic |
description | Oxidized form |
form | powder |
InChI | 1S/C8H14O2S2/c9-8(10)4-2- |
InChI key | AGBQKNBQESQNJD-UHFFFAOYSA |
Quality Level | 200 ![]() |
SMILES string | OC(=O)CCCCC1CCSS1 |
solubility | ethanol: soluble 50 mg/mL |
Application: | α-LA can reinstate endothelial activities and alleviate oxidative stress in high-fat fed diabetic rats4. It has also been used to analyze ROS production in astrocytes5. |
Biochem/physiol Actions: | Antioxidant and coenzyme needed for the activity of enzyme complexes such as those of pyruvate dehydrogenase and glycine decarboxylase. Exogenous thioctic acid is reduced intracellularly by two or more enzymes. The reduced form then influences a number of cell processes by direct radical scavenging, recycling of other antioxidants, increasing glutathione synthesis, and modulating transcription factor activity particularly that of NF-κB. Decreases the phagocytosis of myelin by macrophages. |
Packaging: | 1, 5, 25, 50 g in poly bottle |
Packaging: | 500 mg in poly bottle |
Preparation Note: | (±)-α-Lipoic acid (α-LA) is soluble in ethanol at 50 mg/ml |
Symbol | ![]() ![]() |
Signal word | Warning |
Hazard statements | H302 - H315 - H317 - H319 - H411 |
Precautionary statements | P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 |
Hazard Codes | Xn |
Risk Statements | 22 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 2 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥99% (titration) |
UNSPSC | 12352200 |