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(±)-α-Lipoic acid

SIGMA/T5625 - synthetic, ≥99% (titration), powder

Synonym: (±)-1,2-Dithiolane-3-pentanoic acid; 6,8-Dithiooctanoic acid; DL-α-Lipoic acid; DL-6,8-Thioctic acid; Lip(S2)

CAS Number: 1077-28-7
Empirical Formula (Hill Notation): C8H14O2S2
Molecular Weight: 206.33
EC Number: 214-071-2
MDL Number: MFCD00005474
Linear Formula: C8H14O2S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T5625-500MG 500 mg
 $0.00
1/EA
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45-T5625-1G 1 g
 $38.20
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45-T5625-5G 5 g
 $100.00
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45-T5625-25G 25 g
 $416.00
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45-T5625-50G 50 g
 $691.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: T5625-50G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: T5625-25G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: T5625-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: T5625-500MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: T5625-5G

 

assay ≥99% (titration)
biological source synthetic
description Oxidized form
form powder
InChI 1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)
InChI key AGBQKNBQESQNJD-UHFFFAOYSA-N
Quality Level 200 
SMILES string OC(=O)CCCCC1CCSS1
solubility ethanol: soluble 50 mg/mL
Application: α-LA can reinstate endothelial activities and alleviate oxidative stress in high-fat fed diabetic rats4. It has also been used to analyze ROS production in astrocytes5.
Biochem/physiol Actions: Antioxidant and coenzyme needed for the activity of enzyme complexes such as pyruvate dehydrogenase and glycine decarboxylase.
Biochem/physiol Actions: Antioxidant and coenzyme needed for the activity of enzyme complexes such as those of pyruvate dehydrogenase and glycine decarboxylase. Exogenous thioctic acid is reduced intracellularly by two or more enzymes. The reduced form then influences a number of cell processes by direct radical scavenging, recycling of other antioxidants, increasing glutathione synthesis, and modulating transcription factor activity particularly that of NF-κB. Decreases the phagocytosis of myelin by macrophages.
Packaging: 1, 5, 25, 50 g in poly bottle
Packaging: 500 mg in poly bottle
Preparation Note: (±)-α-Lipoic acid (α-LA) is soluble in ethanol at 50 mg/ml
Purity ≥99% (titration)
UNSPSC 12352106

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