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DL-Thiorphan

SIGMA/T6031 - ≥98% (TLC)

Synonym: (±)-N-(3-Mercapto-2-benzylpropionyl)glycine; DL-3-Mercapto-2-benzylpropanoylglycine

CAS Number: 76721-89-6
Empirical Formula (Hill Notation): C12H15NO3S
Molecular Weight: 253.32
MDL Number: MFCD00058435
Linear Formula: C12H15NO3S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T6031-5MG 5 mg
 $219.00
1/EA		 Add To Favorites
45-T6031-25MG 25 mg
 $765.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T6031-25MG

 

assay ≥98% (TLC)
form powder
InChI 1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15)
InChI key LJJKNPQAGWVLDQ-UHFFFAOYSA-N
mp 138 °C
Quality Level 200 
SMILES string OC(=O)CNC(=O)C(CS)Cc1ccccc1
solubility ethanol: soluble 49.00-51.00 mg/mL, clear, colorless
Application: DL-Thiorphan has been used to evaluate the activity of NEP-dependent neutral endopeptidase. DL-Thiorphan has also been used for determining NEP enzymatic activity using fluorimetric assays.
Biochem/physiol Actions: Enkephalinase inhibitor.
Features and Benefits: This compound is featured on the Neuropeptidases  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description: Thiorphan, also called DL-mercapto-2-benzylpropanoyl-glycine is a specific and potent inhibitor of enkephalinase in nanomolar concentrations. It is an inhibitor of neutral endopeptidase. It interacts with cluster of differentiation 10 (CD10) in bone marrow cells and may modulate hematopoiesis. Thiorphan is a safe drugprescribed for diarrhea. It prevents cortical damage in newborn mice and is a potent agent for treating cerebral palsy.(CP)
Packaging: 5, 25 mg in glass bottle
Preparation Note: DL-Thiorphan is soluble in ethanol at 49.00 - 51.00 mg/ml and yields a clear, colorless solution.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (TLC)
mp 138 °C
UNSPSC 12352200

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