Thio-TEPA
SIGMA/T6069
Synonym: N,N′,N″-Triethylenethiophosphoramide; Thio-Tep; Thiofozil; Thiotef; Tio-tef; Tiofosfamid; Tiofosyl; Tiofozil; Tris(aziridinyl)
CAS Number: 52-24-4
Empirical Formula (Hill Notation): C6H12N3PS
Molecular Weight: 189.22
EC Number: 200-135-7
MDL Number: MFCD00145452
Linear Formula: C6H12N3PS
Product Type: Chemical
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This image depicts SKU: T6069-1G
This image depicts SKU: T6069-1G
| antibiotic activity spectrum | neoplastics |
| color | white |
| form | solid |
| InChI | 1S/C6H12N3PS/c11-10(7-1-2 |
| InChI key | FOCVUCIESVLUNU-UHFFFAOYSA |
| mode of action | DNA synthesis | interferes |
| Quality Level | 200  |
| SMILES string | S=P(N1CC1)(N2CC2)N3CC3 |
| storage condition | (Keep container tightly closed in a dry and well-ventilated place.) |
| storage temp. | 2-8°C |
| Analysis Note: | Solubility - freely soluble in water , in chloroform and in ethanol (96%) |
| Application: | A polyfunctional alkylating agent |
| Biochem/physiol Actions: | The unstable nitrogen-carbon groups alkylate with DNA which causes irreversible DNA damage. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. The DNA strands are unable to uncoil and separate which halts cell division. |
| General description: | Chemical structure: aziridine |
| Other Notes: | Keep container tightly closed in a dry and well-ventilated place. |
| Packaging: | 1 g in poly bottle |
| Symbol |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H300 - H350 |
| Precautionary statements | P201 - P301 + P310 + P330 |
| Hazard Codes | T+ |
| Risk Statements | 45-46-28 |
| Safety Statements | 53-22-26-36/37/39-45 |
| RIDADR | UN 2811 6.1 / PGII |
| WGK Germany | WGK 3 |
| Storage Temp. | 2-8°C |
| UNSPSC | 51102829 |