Trioxsalen
SIGMA/T6137 - ≥98% (HPLC), powder
Synonym: 2,5,9-
CAS Number: 3902-71-4
Empirical Formula (Hill Notation): C14H12O3
Molecular Weight: 228.24
EC Number: 223-459-0
MDL Number: MFCD00005010
Linear Formula: C14H12O3
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T6137-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T6137-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T6137-500MG
| assay | ≥98% (HPLC) |
| color | white |
| fluorescence | λex 269 nm; λem 445 nm in methanol |
| λex 321 nm; λem 445 nm (bound to DNA in Tris, pH 8.1) | |
| form | powder |
| InChI | 1S/C14H12O3/c1-7-4-12(15) |
| InChI key | FMHHVULEAZTJMA-UHFFFAOYSA |
| mp | 229-231 °C (lit.) |
| originator | Valeant |
| Quality Level | 200  |
| SMILES string | Cc1cc2cc3C(C)=CC(=O)Oc3c( |
| solubility | chloroform: soluble 50 mg/mL, clear, colorless to faintly yellow |
| storage temp. | −20°C |
| Application: | Trioxsalen has been used for mutagenesis of N2 worms4,5. |
| Application: | Trioxsalen has been used: • to induce small deletion mutations in worms • in combination with ultraviolet A (UVA) • to induce interstrand crosslinks (ICLs) in DNA • for the preparation and photoactivation of trimethyl psoralen |
| Biochem/physiol Actions: | Photochemical crosslinker of DNA that has been used as a probe for nucleic acid structure and function. Trioxsalen has also been used to crosslink DNA onto mica surfaces. |
| Biochem/physiol Actions: | Trioxsalen (TRX) is a 4,5′,8-trimethylated psoralen analog, which belongs to the family of furocoumarins. It is mostly used to treat psoriasis. |
| Features and Benefits: | This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | This compound was developed by Valeant . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| Packaging: | 1 g in glass bottle |
| Packaging: | 100, 500 mg in glass bottle |
| Preparation Note: | Trioxsalen is soluble in chloroform at 50 mg/ml and yields a clear, colorless to faint yellow solution. |
| Symbol |    GHS05,GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H312 + H332 - H314 - H341 |
| Precautionary statements | P202 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 |
| Hazard Codes | C |
| Risk Statements | 34-40 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 1759 8 / PGII |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| mp | 229-231 °C (lit.) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |