Trazodone hydrochloride

SIGMA/T6154 - ≥99% (HPLC), powder

Synonym: 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one hydrochloride

CAS Number: 25332-39-2
Empirical Formula (Hill Notation): C₁₉H₂₂ClN₅O · HCl
Molecular Weight: 408.32
EC Number: 246-855-5
MDL Number: MFCD00079603
Linear Formula: C₁₉H₂₂ClN₅O · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-T6154-1G	1 g	$74.60 1/EA	Add To Favorites
45-T6154-5G	5 g	$176.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T6154-1G

Properties
Descriptions
Safety Info.
Basic Data

assay	≥99% (HPLC)
form	powder
InChI	1S/C19H22ClN5O.ClH/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25;/h1-3,5-7,9,15H,4,8,10-14H2;1H
InChI key	OHHDIOKRWWOXMT-UHFFFAOYSA-N
originator	Bristol-Myers Squibb
Quality Level	200
SMILES string	Cl[H].Clc1cccc(c1)N2CCN(CCCN3N=C4C=CC=CN4C3=O)CC2
solubility	0.1 M HCl: soluble 7.4 mg/mL
	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 23.3 mg/mL
	DMSO: soluble
	H₂O: soluble, hazy, colorless
	methanol: soluble 25 mg/mL, clear, colorless

Biochem/physiol Actions:	Antidepressant that potentiates the activity of serotonin uptake blockers and has full 5-HT_2C serotonin receptor agonist activity. It is metabolized to the 5-HT₁ serotonin receptor agonist 1-(3-Chlorophenyl)piperazine.
Features and Benefits:	This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits:	This compound was developed by Bristol-Myers Squibb . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging:	1, 5 g in glass bottle
Preparation Note:	Trazodone hydrochloride dissolves in methanol at 25 mg/ml to yield a clear, colorless solution. It also dissolves in water at 50 mg/ml, with heating to yield a hazy colorless solution. Furthermore, the product is soluble in DMSO or in 0.1 N HCl (7.4 mg/ml). The solubility in a 45% (w/v) aqueous 2-hydroxpropyl-β-cyclodextrin is 23.3 mg/ml. However, it is practically insoluble in other common organic solvents. For HPLC test, the product can be dissolved at 0.25 mg/ml in 50:50 water:methanol (v/v), as this gives better results of dissolution and peak shape than using the product as a 1 mg/ml solution in water.

Symbol	GHS07,GHS08
Signal word	Warning
Hazard statements	H302 - H351
Precautionary statements	P201 - P301 + P312 + P330 - P308 + P313
Hazard Codes	Xn
Risk Statements	22-40
Safety Statements	22-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99% (HPLC)
UNSPSC	12352200

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