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Timolol maleate salt

SIGMA/T6394 - ≥98% (TLC), powder

Synonym: S-(−)-1-(t-Butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol maleate salt; Timolol hydrogen maleate

CAS Number: 26921-17-5
Empirical Formula (Hill Notation): C13H24N4O3S · C4H4O4
Molecular Weight: 432.49
EC Number: 248-111-5
MDL Number: MFCD00058356
Linear Formula: C13H24N4O3S · C4H4O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T6394-100MG 100 mg
 $84.70
1/EA		 Add To Favorites
45-T6394-250MG 250 mg
 $178.00
1/EA		 Add To Favorites
45-T6394-1G 1 g
 $535.00
1/EA		 Add To Favorites

 

ε (extinction coefficient) 8,700 at 294 nm at 1 M
assay ≥98% (TLC)
color white to off-white
form powder
InChI 1S/C13H24N4O3S.C4H4O4/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17;5-3(6)1-2-4(7)8/h10,14,18H,4-9H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t10-;/m0./s1
InChI key WLRMANUAADYWEA-NWASOUNVSA-N
mp 202-203 °C (lit.)
optical activity [α]25/D -5.4°, c = 4.9 in 1 M HCl(lit.)
originator Merck & Co., Inc., Kenilworth, NJ, U.S.
Quality Level 200 
SMILES string [H]C(=C(/[H])C(O)=O)C(O)=O.CC(C)(C)NC[C@H](O)COc1nsnc1N2CCOCC2
solubility ethanol: soluble
  H2O: soluble
Application: Timolol maleate has been used as an adrenergic β-blocker for evaluating cardiovascular functions in mice5. It has also been used for evaluating the uptake of 86Rb+ in rat cardiomyocytes6.
Biochem/physiol Actions: Timolol maleate is a class II anti-arrhythmic agent that functions as a non-selective β-adrenoceptor antagonist, a vasodilator and an anti-glaucoma agent. Studies have reported that timolol maleate can be used for the treatment of infantile hemangioma (IH)7.
Features and Benefits: This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S. . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Preparation Note: Timolol maleate is soluble in ethanol and water.
Purity ≥98% (TLC)
mp 202-203 °C (lit.)
UNSPSC 12352200

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