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3,3′,5-Triiodo-L-thyronine sodium salt

SIGMA/T6397 - powder, BioReagent, suitable for cell culture

Synonym: Liothyronine; O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine sodium salt; T3

CAS Number: 55-06-1
Empirical Formula (Hill Notation): C15H11I3NNaO4
Molecular Weight: 672.96
EC Number: 200-223-5
MDL Number: MFCD00002594
Linear Formula: C15H11I3NNaO4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T6397-100MG 100 mg
 $94.70
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45-T6397-250MG 250 mg
 $210.00
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45-T6397-1G 1 g
 $569.00
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assay ≥95%
biological source synthetic
form powder
InChI 1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1
InChI key SBXXSUDPJJJJLC-YDALLXLXSA-M
potency 0.02-50 ng/mL (lit.)
product line BioReagent
Quality Level 200 
shipped in ambient
SMILES string [Na+].N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O
solubility ethanol/1 M HCl (4:1): 10 mg/mL, clear, colorless to yellow
storage temp. −20°C
technique(s) cell culture | mammalian: suitable
Application: 3,3′,5-Triiodo-L-thyronine sodium salt has been used for inducing thyroid hormone manipulations in mice. It has also been used In cell culturing of hippocampal, retinal, proximal tubule and glomerular explant.
Biochem/physiol Actions: 3,3′,5′-Triiodo-L-thyronine (T3) increases the rates of protein synthesis, stimulates the breakdown of cholesterol and effects embryonic development. In cell culture, T3 regulates cell differentiation and protein expression. The interaction of T3 with nonhistone proteins in the chromatin initiates the thyroid hormone activity. Thyroid hormones regulate the differentiation and development of tissues and affect a number of metabolic processes. The level of circulating T3 hormone is reduced in hypothyroidism.
General description: 3,3′,5′-Triiodo-L-thyronine (T3) is an endocrine hormone produced by the thyroid gland and is regarded as an active thyroid hormone at cellular level. Thyroxine (T4) serves as a precursor for T3 and is generated in extrathyroidal tissues.
Physical form: powder-20 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw, solution stable 2-8 °C, 30 days
Preparation Note: To prepare 20 μg/ml stock solution: add 1ml 1N NaOH per mg 3,3′, 5-triiodo-L-thyronine; gently swirl to dissolve. To this, add 49 ml sterile medium per ml 1N NaOH added.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95%
Storage Temp. −20°C
UNSPSC 12352209

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