Anti-TREK-1 antibody produced in rabbit
SIGMA/T6448 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-Kcnk2; Anti-Potassium Channel K2P2.1; Anti-TWIK-related K+ channel 1
MDL Number: MFCD05865392
Product Type: Chemical
Immunoblotting Anti-K2P2.1 (TREK-1): Cat. No. T6448: Western blot analysis of Rat brain membranes. Lanes 1. Anti-K2P2.1 (TREK-1) antibody, (1:200). 2. Anti-K2P2.1 (TREK-1) antibody, preincubated with the control peptide antigen.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| Quality Level | 100  |
| species reactivity | rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot (chemiluminescent): 1:200 using rat brain membranes |
| UniProt accession no. | Q920B6  |
| Application: | Anti-TREK-1 antibody produced in rabbit has been used in western blotting. |
| Application: | Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below. Western Blotting (1 paper) |
| Biochem/physiol Actions: | Potassium two pore domain channel subfamily K member 2 (KCNK2) possesses a potassium channel activity. It has a role in stabilizing the resting membrane potential of cells. The protein is also involved in the development of rat heart. TREK-1 could act as a drug target to treat acute heart ischemia. |
| Biochem/physiol Actions: | The antibody reacts with rat TREK-1 (confirmed). It is expected that the antibody will also react with human and mouse TREK-1 due to sequence homology (17/18). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Potassium two pore domain channel subfamily K member 2 (KCNK2), also known as TWIK-related K+ channel-1 (TREK1), is expressed in the spinal cord, bladder and dorsal root ganglion. It is part of the TREK family. |
| Immunogen: | synthetic peptide (DPKSA AQNSK PRLSF STKC) corresponding to the intracellular, amino terminus of human TREK-1 (amino acid residues 8-28). |
| Physical form: | Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |