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Tyrphostin RG 13022

SIGMA/T6568 - ≥98%

Synonym: 2-(3,4′-Dimethoxyphenyl)-1-(3″-pyridinyl)acrylonitrile

CAS Number: 136831-48-6
Empirical Formula (Hill Notation): C16H14N2O2
Molecular Weight: 266.29
MDL Number: MFCD00236444
Linear Formula: C16H14N2O2
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-T6568-1MG 1 mg
$0.00
1/EA
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45-T6568-5MG 5 mg
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assay ≥98%
form solid
InChI 1S/C16H14N2O2/c1-19-15-6-5-12(9-16(15)20-2)8-14(10-17)13-4-3-7-18-11-13/h3-9,11H,1-2H3
InChI key DBGZNJVTHYFQJI-UHFFFAOYSA-N
mp 114-115 °C
potency IC50 (3 micromolar for inhibition of EGF-receptor.)
Quality Level 200 
SMILES string COc1ccc(cc1OC)C=C(C#N)c2cccnc2
solubility DMSO or ethanol: soluble
storage temp. 2-8°C
Biochem/physiol Actions: Non-phenolic tyrphostin-class tyrosine kinase inhibitor.
Preparation Note: Tyrphostin RG 13022 is known to suppress EGF-induced cancer cell proliferation under in vitro conditions and can also inhibit the growth of tumors in nude mice.
Preparation Note: Tyrphostin RG 13022 is soluble in DMSO and ethanol.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98%
mp 114-115 °C
Storage Temp. 2-8°C
UNSPSC 12352200

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