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TOFA

SIGMA/T6575 - ≥98% (HPLC)

Synonym: 5-(Tetradecyloxy)-2-furoic acid

CAS Number: 54857-86-2
Empirical Formula (Hill Notation): C19H32O4
Molecular Weight: 324.45
MDL Number: MFCD01726059
Linear Formula: C19H32O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T6575-5MG 5 mg
 $233.00
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45-T6575-25MG 25 mg
 $923.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T6575-25MG

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C19H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22-18-15-14-17(23-18)19(20)21/h14-15H,2-13,16H2,1H3,(H,20,21)
InChI key CZRCFAOMWRAFIC-UHFFFAOYSA-N
mp 112-115 °C
SMILES string CCCCCCCCCCCCCCOc1ccc(o1)C(O)=O
solubility DMSO: 2 mg/mL, clear
storage temp. −20°C
Application: TOFA has been used as a lipid biosynthesis inhibitor in mesenchymal stromal cells (MSCs), human pluripotent stem cells., an acetyl-CoA carboxylase 1 inhibitor in murine adipocyte cell lines., a lipolysis inhibitor in cancer stem cells (CSCs).
Application: TOFA has been used as an ACC inhibitor to study its effect on insulin secretion in INS-1E cells.
Biochem/physiol Actions: 5-(Tetradecyloxy)-2-furoic acid (TOFA) elicits hypolipidemic functionality by favoring fatty acid breakdown and at the same time preventing biosynthesis. It induces apoptosis in pancreatic cancer cells and favors tumor suppression.
Biochem/physiol Actions: Studies have reported that TOFA can inhibit the anorectic effect of subcutaneous tamoxifen (TMX) on food intake during refeeding experiments in rats.
Biochem/physiol Actions: TOFA is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC). TOFA is a key enzyme involved in fatty acid biosynthesis. TOFA inhibits cellular fatty acid synthesis in a dose-dependent manner (IC50 = 4 μM in human breast cancer cell line MCF7).
Packaging: 25 mg in poly bottle
Packaging: 5 mg in glass bottle
Preparation Note: TOFA is soluble in DMSO at a concentration that is greater than 2 mg/ml.
RIDADR NONH for all modes of transport
WGK Germany WGK 2
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
mp 112-115 °C
Storage Temp. −20°C
UNSPSC 12352200

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