TOFA
SIGMA/T6575 - ≥98% (HPLC)
Synonym: 5-
CAS Number: 54857-86-2
Empirical Formula (Hill Notation): C19H32O4
Molecular Weight: 324.45
MDL Number: MFCD01726059
Linear Formula: C19H32O4
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C19H32O4/c1-2-3-4-5-6- |
InChI key | CZRCFAOMWRAFIC-UHFFFAOYSA |
mp | 112-115 °C |
SMILES string | CCCCCCCCCCCCCCOc1ccc(o1)C |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | −20°C |
Application: | TOFA has been used as a lipid biosynthesis inhibitor in mesenchymal stromal cells (MSCs), human pluripotent stem cells., an acetyl-CoA carboxylase 1 inhibitor in murine adipocyte cell lines., a lipolysis inhibitor in cancer stem cells (CSCs). |
Application: | TOFA has been used as an ACC inhibitor to study its effect on insulin secretion in INS-1E cells. |
Biochem/physiol Actions: | 5-(Tetradecyloxy)-2-furoi |
Biochem/physiol Actions: | Studies have reported that TOFA can inhibit the anorectic effect of subcutaneous tamoxifen (TMX) on food intake during refeeding experiments in rats. |
Biochem/physiol Actions: | TOFA is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC). TOFA is a key enzyme involved in fatty acid biosynthesis. TOFA inhibits cellular fatty acid synthesis in a dose-dependent manner (IC50 = 4 μM in human breast cancer cell line MCF7). |
Packaging: | 25 mg in poly bottle |
Packaging: | 5 mg in glass bottle |
Preparation Note: | TOFA is soluble in DMSO at a concentration that is greater than 2 mg/ml. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 2 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
mp | 112-115 °C |
Storage Temp. | −20°C |
UNSPSC | 12352200 |