TRAM-34
SIGMA/T6700 - ≥98% (HPLC), solid
Synonym: 1-
CAS Number: 289905-88-0
Empirical Formula (Hill Notation): C22H17ClN2
Molecular Weight: 344.84
MDL Number: MFCD09842562
Linear Formula: C22H17ClN2
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | off-white |
| form | solid |
| InChI | 1S/C22H17ClN2/c23-21-15-8 |
| InChI key | KBFUQFVFYYBHBT-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Clc1ccccc1C(c2ccccc2)(c3c |
| solubility | DMSO: 2 mg/mL |
| H2O: insoluble | |
| storage temp. | 2-8°C |
| Application: | TRAM-34 has been used to study its effect on the prevention of vascular restenosis after balloon angioplasty. |
| Biochem/physiol Actions: | TRAM-34 exhibits 100-fold selectivity (Kd = 20 nM) for IKCa1 channels over other K+ channels (Charybdotoxin, Kd = 5 nM, Clotrimazole, Kd = 70 nM; Nitrendipine Kd = 900 nM). Furthermore, TRAM-34 is known to suppress the activation of human T lymphocytes,. |
| Biochem/physiol Actions: | TRAM-34 is a potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel. |
| Features and Benefits: | This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 5, 25 mg in glass bottle |
| Preparation Note: | TRAM-34 is soluble in DMSO at 2 mg/ml. However, it is insoluble in water. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 - H413 |
| Precautionary statements | P273 - P301 + P312 + P330 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |